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Fig. 5 | BMC Gastroenterology

Fig. 5

From: Carbon tetrachloride (CCl4) accelerated development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet supplemented with fructose (WDF)

Fig. 5

Therapeutic effects of Obeticholic acid (OCA, 30 mg/kg, QD) in Western diet supplemented with fructose (WDF) fed MS-NASH or C57BI/6 mice treated low dose CCl4 (0.08 mL/kg) twice weekly for 8 weeks. Top panel: (a) Body weight; serum (b) ALT and (c) AST. Bottom panel: (d) Terminal liver weight; and liver contents of (e) triglycerides and (f) cholesterol. Data represented as mean ± SEM. * p < 0.05, *** p < 0.005, Veh. vs OCA groups by Holm-Sidak t-test

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