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Table 4 Sensitivity, specificity, and diagnostic accuracy of cut-off and area under the curve values for evaluating liver stiffness in non-SVR patients with liver tumors and hepatitis C viral infection

From: Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection

non-SVR n = 64 + control n = 14 Sensitivity (%) Specificity (%) PPV (%) NPV (%) cut off AUC AUC (p value)
vs FibroScan vs VTQ vs FIB-4 index vs M2BPGi
F0–1 (n = 15) vs F2–4 (n = 63) FibroScan 93 82 93 81 6.2 0.94 Ref 0.226 0.110 0.211
VTQ 82 88 98 88 1.27 0.89 0.226 Ref 0.273 0.361
FIB-4 index 91 69 95 63 1.74 0.85 0.110 0.273 Ref 0.822
M2BPGi 70 63 83 81 1.40 0.77 0.211 0.361 0.822 Ref
F0–2 (n = 36) vs F3–4 (n = 42) FibroScan 91 72 88 71 8.9 0.85 Ref 0.694 0.020 0.003
VTQ 87 82 88 71 1.46 0.84 0.694 Ref 0.049 0.304
FIB-4 index 78 62 79 62 2.91 0.74 0.020 0.049 Ref 0.304
M2BPGi 70 62 70 69 1.76 0.73 0.003 0.304 0.304 Ref
F0–3 (n = 65) vs F4 (n = 13) FibroScan 94 80 79 79 15.0 0.91 Ref 0.593 0.003 0.026
VTQ 94 75 75 75 1.94 0.88 0.593 Ref 0.006 0.049
FIB-4 index 67 57 55 55 3.25 0.67 0.003 0.006 Ref 0.190
M2BPGi 76 69 74 74 2.70 0.78 0.026 0.049 0.190 Ref
  1. VTQ Virtual-Touch tissue quantification, M2BPGi Mac-2 binding protein glycosylation isomer, AUC area under the curve, PPV positive predictive value, NPV negative predictive value