Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection

Table 4 Sensitivity, specificity, and diagnostic accuracy of cut-off and area under the curve values for evaluating liver stiffness in non-SVR patients with liver tumors and hepatitis C viral infection

non-SVR n = 64 + control n = 14		Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	cut off	AUC	AUC (p value)
non-SVR n = 64 + control n = 14		Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	cut off	AUC	vs FibroScan	vs VTQ	vs FIB-4 index	vs M2BPGi
F0–1 (n = 15) vs F2–4 (n = 63)	FibroScan	93	82	93	81	6.2	0.94	Ref	0.226	0.110	0.211
	VTQ	82	88	98	88	1.27	0.89	0.226	Ref	0.273	0.361
	FIB-4 index	91	69	95	63	1.74	0.85	0.110	0.273	Ref	0.822
	M2BPGi	70	63	83	81	1.40	0.77	0.211	0.361	0.822	Ref
F0–2 (n = 36) vs F3–4 (n = 42)	FibroScan	91	72	88	71	8.9	0.85	Ref	0.694	0.020	0.003
	VTQ	87	82	88	71	1.46	0.84	0.694	Ref	0.049	0.304
	FIB-4 index	78	62	79	62	2.91	0.74	0.020	0.049	Ref	0.304
	M2BPGi	70	62	70	69	1.76	0.73	0.003	0.304	0.304	Ref
F0–3 (n = 65) vs F4 (n = 13)	FibroScan	94	80	79	79	15.0	0.91	Ref	0.593	0.003	0.026
	VTQ	94	75	75	75	1.94	0.88	0.593	Ref	0.006	0.049
	FIB-4 index	67	57	55	55	3.25	0.67	0.003	0.006	Ref	0.190
	M2BPGi	76	69	74	74	2.70	0.78	0.026	0.049	0.190	Ref

VTQ Virtual-Touch tissue quantification, M2BPGi Mac-2 binding protein glycosylation isomer, AUC area under the curve, PPV positive predictive value, NPV negative predictive value

ISSN: 1471-230X