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Table 3 Sensitivity, specificity, and diagnostic accuracy of cut-off and area under the curve values for evaluating liver stiffness in all patients with liver tumors and hepatitis C viral infection

From: Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection

HCC n = 94 + control n = 14 Sensitivity (%) Specificity (%) PPV (%) NPV (%) cut off AUC AUC (p value)
vs FibroScan vs VTQ vs FIB-4 index vs M2BPGi
F0–1 (n = 16) vs F2–4 (n = 92) FibroScan 95 86 90 73 5.6 0.95 Ref 0.602 0.110 0.211
VTQ 87 86 95 54 1.26 0.93 0.602 Ref 0.233 0.361
FIB-4 index 98 72 93 83 1.74 0.87 0.110 0.233 Ref 0.822
M2BPGi 74 71 96 76 1.63 0.81 0.211 0.361 0.822 Ref
F0–2 (n = 52) vs F3–4 (n = 56) FibroScan 88 74 84 83 9.8 0.85 Ref 0.649 0.002 0.001
VTQ 81 81 87 76 1.78 0.83 0.649 Ref 0.010 0.002
FIB-4 index 73 52 69 65 3.20 0.67 0.002 0.010 Ref 0.471
M2BPGi 66 59 70 55 2.15 0.67 0.001 0.002 0.471 Ref
F0–3 (n = 91) vs F4 (n = 17) FibroScan 83 82 63 97 16.0 0.89 Ref 0.453 0.002 0.029
VTQ 92 70 65 98 1.94 0.86 0.453 Ref 0.045 0.087
FIB-4 index 58 55 67 88 4.56 0.65 0.002 0.045 Ref 0.215
M2BPGi 75 62 66 93 2.70 0.76 0.029 0.087 0.215 Ref
  1. VTQ Virtual-Touch tissue quantification, M2BPGi Mac-2 binding protein glycosylation isomer, AUC area under the curve, PPV positive predictive value, NPV negative predictive value