Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection

Table 3 Sensitivity, specificity, and diagnostic accuracy of cut-off and area under the curve values for evaluating liver stiffness in all patients with liver tumors and hepatitis C viral infection

HCC n = 94 + control n = 14		Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	cut off	AUC	AUC (p value)
HCC n = 94 + control n = 14		Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	cut off	AUC	vs FibroScan	vs VTQ	vs FIB-4 index	vs M2BPGi
F0–1 (n = 16) vs F2–4 (n = 92)	FibroScan	95	86	90	73	5.6	0.95	Ref	0.602	0.110	0.211
	VTQ	87	86	95	54	1.26	0.93	0.602	Ref	0.233	0.361
	FIB-4 index	98	72	93	83	1.74	0.87	0.110	0.233	Ref	0.822
	M2BPGi	74	71	96	76	1.63	0.81	0.211	0.361	0.822	Ref
F0–2 (n = 52) vs F3–4 (n = 56)	FibroScan	88	74	84	83	9.8	0.85	Ref	0.649	0.002	0.001
	VTQ	81	81	87	76	1.78	0.83	0.649	Ref	0.010	0.002
	FIB-4 index	73	52	69	65	3.20	0.67	0.002	0.010	Ref	0.471
	M2BPGi	66	59	70	55	2.15	0.67	0.001	0.002	0.471	Ref
F0–3 (n = 91) vs F4 (n = 17)	FibroScan	83	82	63	97	16.0	0.89	Ref	0.453	0.002	0.029
	VTQ	92	70	65	98	1.94	0.86	0.453	Ref	0.045	0.087
	FIB-4 index	58	55	67	88	4.56	0.65	0.002	0.045	Ref	0.215
	M2BPGi	75	62	66	93	2.70	0.76	0.029	0.087	0.215	Ref

VTQ Virtual-Touch tissue quantification, M2BPGi Mac-2 binding protein glycosylation isomer, AUC area under the curve, PPV positive predictive value, NPV negative predictive value

ISSN: 1471-230X