Extra-hepatic comorbidity burden significantly increases 90-day mortality in patients with cirrhosis and high model for endstage liver disease

Table 4 The factors associated with overall mortality in the competing-risk regression analysis with liver transplantation as the competing risk

Factor	Univariable analysis			Multivariable analysis
Factor	Sub-Hazard ratio	95% confidence interval	P-value	Sub-Hazard ratio	95% confidence interval	P-value
CCI	1.25	(1.14–1.38)	< 0.001	1.24	(1.1–1.4)	< 0.001
MELD-Na	1.05	(1.02–1.08)	0.002	1.05	(1.02–1.09)	0.001
Age	1.01	(0.99–1.02)	0.2	1.01	(0.99–1.03)	0.2
Male gender	1.2	(0.9–1.6)	0.3	0.94	(0.7–1.3)	0.7
Body mass index	1.01	(0.98–1.03)	0.5	1.01	(0.98–1.03)	0.7
Race (reference white)
Black	0.9	(0.5–1.7)	0.7	0.8	(0.4–1.7)	0.5
Hispanic	1.5	(0.7–3.3)	..3	1.4	(0.5–3.5)	0.6
Asian	1.3	(0.4–5)	0.7	3.1	(1.6–5.7)	0.001
Etiology liver disease (Reference alcohol)
Alcohol and viral	1.7	(1.02–2.7)	0.03	1.6	(0.96–2.67)	0.07
Viral	1.2	(0.8–1.8)	0.4	1.1	(0.7–1.8)	0.6
Autoimmune	0.2	(0.08–0.6)	0.006	0.2	(0.09–0.7)	0.009
Fatty liver	1.1	(0.7–1.7)	0.7	0.9	(0.6–1.6)	0.8
Cryptogenic	1.1	(0.5–2.7)	0.8	0.7	(0.4–2.2)	0.8
Hepatocellular carcinoma	1.3	(0.9–1.7)	0.14	1.1	(0.7–1.6)	0.7

Abbreviations: CCI Charlson Comorbidity Index (excluding liver disease and liver cancer), MELD-Na Model for End-stage Liver Disease with sodium modification, NA not applicable

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