Characteristic | MRCP | Cytology | FISH | FISH & cytology |
|---|
Sensitivity | 26.9%(14/52) | 40.4%(21/52) | 76.9%(40/52) | 78.8%(41/52) |
Specificity | 50.0%(7/14) | 100%(14/14) | 92.9%(13/14) | 92.9%(13/14) |
PPV | 66.7%(14/21) | 100%(21/21) | 97.6%(40/41) | 97.6%(41/42) |
NPV | 15.6%(7/45) | 31.1%(14/45) | 52.0%(13/25) | 54.2%(13/24) |
AUC(95%CI) | ‡0.385 (0.212–0.557) | *0.702 (0.573–0.831) | *0.849 (0.742–0.956) | *§0.859 (0.754–0.963) |
- Sensitivity = True positive/(True positive+False negative)
- Specificity = True negative/(True negative+False positive)
- PPV = True positive/(True positive+False positive)
- NPV = True negative/(True negative+False negative)
- FISH & cytology FISH combined cytology, FISH fluorescence in situ hybridization, MRCP endoscopic Retrograde Cholangiopancreatography, PPV positive predictive value, NPV negative predictive value, AUC area under the curve, CI confidence interval
- *P <0.01 represents difference compared with the cytology alone diagnostic strategy
- ‡ P = 0.021 represents difference compared MRCP with the cytology diagnostic strategy
- §P = 1.000 represents comparison between FISH and FISH combined cytology
