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Table 2 Cox regression analysis for variables associated with 90-day mortality in patients with HBV-ACLF

From: A novel predictive model based on inflammatory markers to assess the prognosis of patients with HBV-related acute-on-chronic liver failure: a retrospective cohort study

Variables Univariate analysis Multivariate analysis
HR
95%(CI)
P value Beta coefficient HR
95%(CI)
P value
TBIL (μmol/L) 1.005
(1.004–1.005)
< 0.001 0.003 1.002
(1.001–1.003)
< 0.001
Cr (μmol/L) 1.008
(1.005–1.010)
< 0.001 0.003 1.003
(1.001–1.005)
0.001
Cyst-c (mg/L) 1.055
(1.014–1.097)
0.008    
Serum Na+(mmol/L) 0.981
(0.959–1.004)
0.112    
INR 1.488
(1.342–1.651)
< 0.001 0.317 1.318
(1.163–1.494)
< 0.001
PTA (%) 0.973
(0.959–0.988)
< 0.001    
WBC (109/L) 1.068
(1.043–1.094)
< 0.001    
Neutrophils (109/L) 1.082
(1.055–1.110)
< 0.001    
Monocytes(109/L) 1.080
(0.997–1.170)
0.060    
Lymphocytes(109/L) 0.856
(0.640–1.144)
0.293    
RDW (%) 1.112
(1.075–1.15)
< 0.001 0.053 1.047
(1.009–1.086)
0.015
NLR 1.053
(1.038–1.068)
< 0.001 0.027 1.027
(1.009–1.046)
0.003
MLR 1.057
(1.007–1.109)
0.025    
PLR 1.003
(1.001–1.005)
0.001    
RLR 1.016
(1.007–1.026)
0.001    
HE 1.221     
  (1.101–1.353) < 0.001    
Bacterial infection 0.55     
  (0.383–0.785) 0.001    
  1. TBIL total bilirubin, ALB albumin, Cr creatinine, Cyst-c Cystatin c, Serum Na+ serum sodium, PT prothrombin time, INR international normalized ratio, PTA prothrombin activity, WBC white blood cell count, RDW red blood cell distribution width, NLR neutrophil/lymphocyte ratio, MLR monocyte/lymphocyte ratio, PLR platelet/lymphocyte ratio, RLR RDW/lymphocyte ratio, HE Hepatic encephalopathy, HBV-ACLF hepatitis B virus related acute-on-chronic liver failure