Table 1 Schematic overview of the clinical course and associated histopathological attributes
Year | 2006 | 2008 | 2008 | 2008 |
|---|---|---|---|---|
Surgery | Primary surgery (abdomino-perineal resection) | Resection of first recurrence | Resection of second recurrence | Resection of third recurrence |
Diagnosis | Primary ANEC with regional lymph node metastases | Inguinal lymph node metastasis | Inguinal lymph node metastasis | Abdominal wall metastasis |
Tumor size (cm) | 5.9 | 3.7 | 4.0 | 7.0 |
Chromogranin A IHC | Positive | Negative | Negative | Negative |
Synaptophysin IHC | Positive | Positive | Positive | Positive |
Ki-67 index | 80% | 90% | 90% | 90% |
Adjuvant chemotherapy | Cisplatin, Etoposide | – | Doxorubicin, Docetaxel | Irinotecan, Fluorouracil |
Adjuvant radiotherapy | 46.8 Gy | – | 12.6 Gy | – |