Metastatic pancreatic adenocarcinomas could be classified into M1a and M1b category by the number of metastatic organs

Table 2 Univariable analysis for mPA patients

Variables	Single Metastasis (n = 9425)^c		Multiple Metastases (n = 2460)^c
Variables	HR^a(95% CI^b)	P value	HR (95% CI)	P value
Gender
Male	Reference		Reference
Female	0.938 (0.898–0.980)	0.004	0.931 (0.856–1.013)	0.095
Age (years)
≤ 65	Reference		Reference
> 65	1.460 (1.397–1.526)	< 0.001	1.344 (1.235–1.461)	< 0.001
Race
White	Reference		Reference
Black	1.075 (1.009–1.145)	0.026	1.007 (0.890–1.140)	0.907
Others	0.981 (0.902–1.067)	0.655	1.053 (0.904–1.227)	0.505
Tumor location
Head	Reference		Reference
Body/tail	1.013 (0.962–1.067)	0.627	1.014 (0.912–1.128)	0.795
Others	1.138 (1.077–1.202)	< 0.001	1.093 (0.980–1.220)	0.112
Marital status
Married	Reference		Reference
Unmarried/unknown	1.231 (1.178–1.286)	< 0.001	1.246 (1.146–1.355)	< 0.001
Grade
Well/moderately differentiated	Reference		Reference
Poorly differentiated/undifferentiated	1.718 (1.566–1.884)	< 0.001	1.531 (1.273–1.840)	< 0.001
Unknown	1.630 (1.515–1.753)	< 0.001	1.411 (1.216–1.637)	< 0.001
Tumor size	1.000 (0.999–1.001)	0.767	1.000 (0.999–1.001)	0.426
Surgery
No	Reference		Reference
Yes	0.513 (0.461–0.572)	< 0.001	0.749 (0.584–0.961)	0.023
Chemotherapy
No	Reference		Reference
Yes	0.432 (0.413–0.452)	< 0.001	0.350 (0.320–0.382)	< 0.001
Radiotherapy
No	Reference		Reference
Yes	0.737 (0.657–0.827)	< 0.001	0.729 (0.635–0.838)	< 0.001

^aHR hazard ratio
^bCI confidence interval
^cThe number of events for patients with single metastasis and multiple metastases were 8077 and 2229, respectively

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