Fig. 4
From: Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas
The protein-protein interaction network between DEGs of HCT-8 and 5-FU resistance-related genes in CRC. The network was consisted of DEGs of HCT-8 treated by melatonin and 5-FU resistance-related genes in CRC. The node shapes represent the types of genes. Ellipse, 5-FU resistance-related genes, of which overexpression are positively related with 5-FU resistance. Rectangle, DEGs of HCT-8 after melatonin treatment. The node colors indicate genes upregulated (Red), downregulated (Green) or non-differentially expressed (Blue) in HCT-8 after melatonin treatment