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Table 2 Demographic and clinical characteristics according to known HIV and HBsAg status

From: Hepatitis B virus-associated hepatocellular carcinoma in South Africa in the era of HIV

 

HIV+ HBV+

HIV- HBV+

HIV+ HBV-

HIV- HBV-

 
 

18 (18%)

47 (47%)

4 (4%)

31 (31%)

p-value

Age groups (in years)

18–34

4 (22)

15 (32)

1 (25)

8 (26)

 

35–49

12 (67)

13 (28)

2 (50)

5 (16)

0.04

50–59

1 (5.5)

11 (23)

1 (25)

12 (39)

 

60–90

1 (5.5)

8 (17)

0 (0)

6 (19)

Gender

Male

12 (67)

41 (87)

2 (50)

23 (74)

0.1

Female

6 (33)

6 (13)

2 (50)

8 (26)

Ethnicity

Black African

16 (89)

23 (50)

4 (100)

9 (32)

0.006

Caucasian

0 (0)

3 (7)

0 (0)

3 (11)

Mixed ancestry

2 (11)

20 (43)

0 (0)

16 (57)

Missing data

0

1

0

3

Alcohol dependence

Yes

4 (22)

8 (18)

1 (3)

7 (25)

0.9

No

14 (78)

36 (82)

2 (67)

21 (75)

Missing data

0

3

1

0

Known cirrhosis

Yes

5 (29)

12 (27)

0 (0)

3 (13)

0.4

No

12 (71)

32 (73)

3 (100)

20 (87)

Missing data

1

3

1

5

HBeAg positive

Yes

10 (59)

9 (20)

n/a

n/a

0.003

No

7 (41)

37 (80)

  

Missing data

1

1

  

HBV genotypes

A

9 (100)

25 (76)

n/a

n/a

0.00009

D

0 (0)

7 (21)

  

E

0 (0)

1 (3)

  

AFP > 400 μg/L

Yes

11 (61)

35 (80)

3 (75)

14 (54)

0.1

No

7 (39)

9 (20)

1 (25)

12 (46)

Missing data

0

3

0

5

Child-Pugh

A

9 (60)

30 (68)

2 (67)

14 (59)

1.0

B

5 (33)

11 (25)

1 (33)

8 (33)

C

1 (7)

3 (7)

0 (0)

2 (8)

Missing data

3

3

1

7

Nodules at diagnosis

Single lesion < 2 cm

3 (19)

5 (12)

0 (0)

4 (14)

 

Single lesion 2–5 cm

0 (0)

0 (0)

0 (0)

1 (4)

1.0

Single lesion > 5 cm

2 (12)

6 (14)

0 (0)

4 (14)

Multiple lesions

11 (69)

31 (74)

1 (100)

19 (68)

Missing data

2

5

1

3

  1. Missing/unknown data, (including cases with unknown HIV status) are excluded from the table and statistical analysis