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Table 4 Elevated plasma and liver cytokine levels in GAN DIO-NASH mice

From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

Cytokine/
chemokine
Chow-fed C57BL/6 J mice GAN DIO-NASH mice
Plasma
(pg/ml)
Liver
(pg/g tissue)
Plasma
(pg/ml)
Liver
(pg/g tissue)
TNF-α 7.4 ± 0.4 33 ± 2.8 15 ± 1.1*** 78 ± 9.7***
IL-1β n.d. 349 ± 46 n.d. 591 ± 79*
IL-2 n.d. n.d. n.d. n.d.
IL-4 n.d. n.d. n.d. n.d.
IL-5 1.9 ± 0.3 9.5 ± 0.7 2.0 ± 0.3 12.4 ± 0.7*
IL-6 8.2 ± 1.0 507 ± 19.7 53.7 ± 18.0* 478 ± 30
IL-10 14 ± 0.5 91 ± 7.2 18 ± 1.6* 97 ± 7.1
IL12p70 n.d. 530 ± 79 n.d. 658 ± 44
INF-γ n.d. 9.9 ± 1.1 n.d. 9.0 ± 1.9
KC/GRO 58 ± 7.4 352 ± 32 138 ± 9.8*** 640 ± 91**
MCP-1 11 ± 0.8 171 ± 9.3 30 ± 4.7** 1759 ± 304***
  1. Plasma and liver cytokine levels in GAN DIO-NASH mice. n.d., not detected (below lower level of quantification; IL-1β, 0.42 pg/ml; IL-2, 0.66 pg/ml; IL-4, 0.42 pg/ml; IL12p70, 7.69 pg/ml; INF-γ, 0.23 pg/ml). *p < 0.05, **p < 0.01, ***p < 0.001, unpaired t-test (chow-fed mice, n = 8; GAN DIO-NASH mice, n = 8)