Table 4 Elevated plasma and liver cytokine levels in GAN DIO-NASH mice
From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
Cytokine/ chemokine | Chow-fed C57BL/6 J mice | GAN DIO-NASH mice | ||
|---|---|---|---|---|
Plasma (pg/ml) | Liver (pg/g tissue) | Plasma (pg/ml) | Liver (pg/g tissue) | |
TNF-α | 7.4 ± 0.4 | 33 ± 2.8 | 15 ± 1.1*** | 78 ± 9.7*** |
IL-1β | n.d. | 349 ± 46 | n.d. | 591 ± 79* |
IL-2 | n.d. | n.d. | n.d. | n.d. |
IL-4 | n.d. | n.d. | n.d. | n.d. |
IL-5 | 1.9 ± 0.3 | 9.5 ± 0.7 | 2.0 ± 0.3 | 12.4 ± 0.7* |
IL-6 | 8.2 ± 1.0 | 507 ± 19.7 | 53.7 ± 18.0* | 478 ± 30 |
IL-10 | 14 ± 0.5 | 91 ± 7.2 | 18 ± 1.6* | 97 ± 7.1 |
IL12p70 | n.d. | 530 ± 79 | n.d. | 658 ± 44 |
INF-γ | n.d. | 9.9 ± 1.1 | n.d. | 9.0 ± 1.9 |
KC/GRO | 58 ± 7.4 | 352 ± 32 | 138 ± 9.8*** | 640 ± 91** |
MCP-1 | 11 ± 0.8 | 171 ± 9.3 | 30 ± 4.7** | 1759 ± 304*** |