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Table 3 Elevated plasma and liver biochemical markers in GAN DIO-NASH mice

From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

 

Chow-fed C57BL/6 J mice

GAN DIO-NASH mice

Plasma ALT (U/L)

29.5 ± 1.9

166 ± 16***

Plasma AST (U/L)

65.4 ± 3.8

196 ± 16.8***

Plasma total CK-18 (ng/ml)

0.11 ± 0.02

0.83 ± 0.12***

Plasma MMP-9 (pg/ml)

15,409 ± 554

21,445 ± 990***

Plasma TIMP-1 (pg/ml)

1151 ± 56

4099 ± 453***

Liver TG (mg/g tissue)

7.4 ± 0.7

94.0 ± 5.4***

Liver TC (mg/g tissue)

2.0 ± 0.1

14.1 ± 0.6***

Liver HP (μg/mg tissue)

0.03 ± 0.01

0.08 ± 0.01***

Liver MMP-9 (pg/g tissue)

183,196 ± 7725

328,529 ± 80,679

  1. Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, CK-18 cytokeratin-18, FFA free fatty acids, HP hydroxyproline, MMP-9 matrix metalloproteinase-9, TC total cholesterol, TG triglycerides; TIMP-1 tissue inhibitor of metalloproteinase-1.
  2. ***p < 0.001, unpaired t-test (chow-fed mice, n = 10; GAN DIO-NASH mice, n = 15)
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BMC Gastroenterology

ISSN: 1471-230X

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