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Table 3 Elevated plasma and liver biochemical markers in GAN DIO-NASH mice

From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

  Chow-fed C57BL/6 J mice GAN DIO-NASH mice
Plasma ALT (U/L) 29.5 ± 1.9 166 ± 16***
Plasma AST (U/L) 65.4 ± 3.8 196 ± 16.8***
Plasma total CK-18 (ng/ml) 0.11 ± 0.02 0.83 ± 0.12***
Plasma MMP-9 (pg/ml) 15,409 ± 554 21,445 ± 990***
Plasma TIMP-1 (pg/ml) 1151 ± 56 4099 ± 453***
Liver TG (mg/g tissue) 7.4 ± 0.7 94.0 ± 5.4***
Liver TC (mg/g tissue) 2.0 ± 0.1 14.1 ± 0.6***
Liver HP (μg/mg tissue) 0.03 ± 0.01 0.08 ± 0.01***
Liver MMP-9 (pg/g tissue) 183,196 ± 7725 328,529 ± 80,679
  1. Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, CK-18 cytokeratin-18, FFA free fatty acids, HP hydroxyproline, MMP-9 matrix metalloproteinase-9, TC total cholesterol, TG triglycerides; TIMP-1 tissue inhibitor of metalloproteinase-1.
  2. ***p < 0.001, unpaired t-test (chow-fed mice, n = 10; GAN DIO-NASH mice, n = 15)