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Table 1 Comparison of liver biopsy histopathology scores in human NASH patients and GAN DIO-NASH mice

From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

  Group n Steatosis score Inflammation score Ballooning score Fibrosis stage
0 1 2 3 0 1 2 3 0 1 2 0 1 2 3 4
Human subjects Healthy normal-weight 14 13 1 14   14 14
NASH 16 2 14 16   10 6 3 12 1
C57BL/6 J mice Chow-fed lean mice 10 10 10   10 10
GAN DIO-NASH mice 25 25 6 13 6 18 7 3 10 11 1
  1. Histopathology scores in liver biopsy samples from normal controls, human NASH patients and GAN DIO-NASH mice. Histopathology was scored according to the criteria outlined by the NASH-Clinical Research Network [27].