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Fig. 2 | BMC Gastroenterology

Fig. 2

From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

Fig. 2

Liver transcriptome changes in human NASH patients and GAN DIO-NASH mice. a Principal component analysis (PCA) of samples based on top 500 most variable gene expression levels. b Venn diagram depicting shared and separate differentially expressed genes (DEGs; false discovery rate < 0.05) in NASH patients and GAN DIO-NASH mice. c Comparison of significantly regulated disease-associated Reactome signalling pathways in NASH patients (n = 16) and GAN-DIO NASH mice (n = 25). Reactome signalling pathways are grouped according to biological pathway. Color gradients indicate significantly upregulated (red color) and downregulated (blue color) pathways compared to corresponding control group (chow-fed mice, n = 10; healthy normal-weight human individuals, n = 14)

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