Fig. 1
From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
Similar liver histopathological hallmarks in human NASH patients and GAN DIO-NASH mice. Upper panels: Representative photomicrographs of liver sections from human healthy normal-weight individual (a), NASH patient (b-e), chow-fed mouse (f) and GAN DIO-NASH mouse (g-j) stained with hematoxylin-eosin (HE, for evaluation of steatosis, inflammation and hepatocyte ballooning; a-d, f-i) or picro-Sirius Red (PSR, for evaluation of fibrosis; e, j). Arrows indicate inflammatory foci and ballooning hepatocytes, respectively. Lower panels: Histomorphometric quantitative assessment of liver lipid accumulation (HE staining), inflammation (galectin-3 immunostaining) and fibrosis (PSR staining) in human and mouse liver biopsy sections. *p < 0.05, **p < 0.01, ***p < 0.001 vs. corresponding control group, unpaired t-test