Lauren’s Types Gastric Adenocarcinoma | ||
---|---|---|
Characteristic | Intestinal | Diffuse |
Incidence trend | declining | stable or increasing |
Prevalence in endemic areas | higher | lower |
Environmental influence | strong | weak |
Age of occurrence | elderly | young |
Genetic factors | weak | strong |
Male/female ratio | 2:1 | 1:1 |
Location of tumor | distal | proximal |
Macroscopic growth pattern | growth into the lumen | tumour spreads along the gastric wall |
Carcinogenesis | well known | unknown |
TCGA subtypes | mainly chromosomal instability (CIN) | mainly genomically stable (GS) |
Prognosis | better | worse |