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Table 1 Differences between Lauren’s intestinal and diffuse types

From: The diffuse-type gastric cancer epidemiology enigma

 

Lauren’s Types Gastric Adenocarcinoma

Characteristic

Intestinal

Diffuse

Incidence trend

declining

stable or increasing

Prevalence in endemic areas

higher

lower

Environmental influence

strong

weak

Age of occurrence

elderly

young

Genetic factors

weak

strong

Male/female ratio

2:1

1:1

Location of tumor

distal

proximal

Macroscopic growth pattern

growth into the lumen

tumour spreads along the gastric wall

Carcinogenesis

well known

unknown

TCGA subtypes

mainly chromosomal instability (CIN)

mainly genomically stable (GS)

Prognosis

better

worse