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Table 3 Subgroup analysis of the diagnostic accuracy for circulating miRNA in HBV-HCC patients with low AFP

From: The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis

  SEN (95%CI) SPE (95%CI) AUC (95%CI) number of data sets number of HCC number of non-HCC heterogeneity (OR-I2)
Specimen
 Serum 0.83 (0.78–0.86) 0.79 (0.69–0.86) 0.87 (0.83–0.89) 13 631 886 69.7%
 Plasma 0.92 (0.52–0.99) 0.72 (0.61–0.81) 0.80 (0.77–0.84) 5 238 452 79.2%
Conference test
 histology 0.85 (0.79–0.90) 0.74 (0.63–0.82) 0.88 (0.85–0.90) 12 683 684 69.0%
 histology or imaging 0.79 (0.64–0.89) 0.81 (0.72–0.88) 0.87 (0.84–0.90) 6 186 654 77.2%
Study design
 case-control 0.84 (0.84–0.84) 0.67 (0.67–0.67) 0.80 (0.76–0.83) 12 565 595 58.3%
 cohort 0.85 (0.74–0.92) 0.89 (0.85–0.91) 0.92 (0.90–0.94) 6 304 743 48.3%
miRNAs profiling
 single 0.84 (0.73–0.91) 0.66 (0.60–0.72) 0.76 (0.72–0.79) 10 435 517 56.0%
 panel 0.83 (0.76–0.88) 0.86 (0.79–0.91) 0.89 (0.86–0.92) 8 434 821 63.5%
QUADAS score
  ≥ 9 0.85 (0.77–0.90) 0.81 (0.73–0.88) 0.90 (0.87–0.92) 8 375 545 53.8%
 <9 0.83 (0.72–0.90) 0.72 (0.60–0.81) 0.85 (0.81–0.88) 10 494 793 76.2%
  1. HBV hepatitis B virus, HCC hepatocellular carcinoma, HBV-HCC, hepatitis B virus-associated HCC, AFP alpha-fetoprotein, miRNAs microRNAs, SEN sensitivity, SPE specificity, AUC area under the curve, OR odds ratio QUADAS. Quality Assessment of Diagnostic Accuracy Studies