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Table 2 Diagnostic accuracy of circulating miRNAs in HBV-HCC patients with low AFP level or AFP negative HBV-HCC patients

From: The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis

miRNA AFP level number of data sets number of HCC number of non-HCC SEN (95%CI) SPE (95%CI) AUC (95%CI)
15b, 130b <400 ng/ml 1 16 59 1 0.92 0.98
15b, 130b <20 ng/ml 1 30 59 0.97 0.92 0.98
125b <20 ng/ml 1 38 48 0.76 0.79 0.78
125b <400 ng/ml 1 31 158 1 0.76 0.94
223 <20 ng/ml 1 38 48 0.79 0.70 0.76
27a <20 ng/ml 1 38 48 0.84 0.72 0.83
26a <20 ng/ml 1 38 48 0.87 0.57 0.73
122 <20 ng/ml 1 92 30 0.71 0.58 0.63
7b <20 ng/ml 1 92 30 0.85 0.51 0.65
122, 7b <20 ng/ml 1 92 30 0.85 0.50 0.65
126 <400 ng/ml 2 36 58 0.61 0.66 0.50
205 <400 ng/ml 1 32 49 1 0.56 0.82
125b, 223, 27a, 26a <20 ng/ml 1 38 48 0.84 0.85 0.87
122, 223, 26a, 27a, 192, 21, 801 <400 ng/ml 1 139 187 0.78 0.85 0.88
29a, 29c, 133a, 143, 145, 192, 505 <20 ng/ml 3 119 438 0.77 0.88 0.64
overall <20 ng/ml 12 615 827 0.85 (0.79–0.90) 0.74 (0.63–0.82) 0.88 (0.85–0.90)
overall <400 ng/ml 18 869 1338 0.84 (0.78–0.88) 0.76 (0.69–0.83) 0.88 (0.84–0.90)
  1. miRNAs microRNAs, AFP alpha-fetoprotein, HBV hepatitis B virus, HCC hepatocellular carcinoma, HBV-HCC hepatitis B virus-associated HCC, SEN sensitivity, SPE specificity, AUC area under the curve