The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis

Table 2 Diagnostic accuracy of circulating miRNAs in HBV-HCC patients with low AFP level or AFP negative HBV-HCC patients

miRNA	AFP level	number of data sets	number of HCC	number of non-HCC	SEN (95%CI)	SPE (95%CI)	AUC (95%CI)
15b, 130b	<400 ng/ml	1	16	59	1	0.92	0.98
15b, 130b	<20 ng/ml	1	30	59	0.97	0.92	0.98
125b	<20 ng/ml	1	38	48	0.76	0.79	0.78
125b	<400 ng/ml	1	31	158	1	0.76	0.94
223	<20 ng/ml	1	38	48	0.79	0.70	0.76
27a	<20 ng/ml	1	38	48	0.84	0.72	0.83
26a	<20 ng/ml	1	38	48	0.87	0.57	0.73
122	<20 ng/ml	1	92	30	0.71	0.58	0.63
7b	<20 ng/ml	1	92	30	0.85	0.51	0.65
122, 7b	<20 ng/ml	1	92	30	0.85	0.50	0.65
126	<400 ng/ml	2	36	58	0.61	0.66	0.50
205	<400 ng/ml	1	32	49	1	0.56	0.82
125b, 223, 27a, 26a	<20 ng/ml	1	38	48	0.84	0.85	0.87
122, 223, 26a, 27a, 192, 21, 801	<400 ng/ml	1	139	187	0.78	0.85	0.88
29a, 29c, 133a, 143, 145, 192, 505	<20 ng/ml	3	119	438	0.77	0.88	0.64
overall	<20 ng/ml	12	615	827	0.85 (0.79–0.90)	0.74 (0.63–0.82)	0.88 (0.85–0.90)
overall	<400 ng/ml	18	869	1338	0.84 (0.78–0.88)	0.76 (0.69–0.83)	0.88 (0.84–0.90)

miRNAs microRNAs, AFP alpha-fetoprotein, HBV hepatitis B virus, HCC hepatocellular carcinoma, HBV-HCC hepatitis B virus-associated HCC, SEN sensitivity, SPE specificity, AUC area under the curve

ISSN: 1471-230X