Subgroup analysis | No. of Studies | Pooled estimates (random-effects model) | ||
---|---|---|---|---|
Relative risk (95% CI) | P value | I2 statistics | ||
The risk of RA in IBD | 8 | 2.59 (1.93–3.48) | 0.000 | 94.2% |
Study design | ||||
 Cross-sectional | 3 | 2.84 (1.85–4.37) | 0.000 | 88.1% |
 Case-control | 2 | 1.62 (0.32–8.07) | 0.557 | 92.9% |
 Retrospective cohort | 3 | 3.16 (2.26–4.41) | 0.000 | 89.4% |
Age | ||||
 Children | 1 | 9.60 (3.90–23.80) | 0.000 | – |
 Adult | 5 | 2.20 (1.53–3.17) | 0.000 | 95.6% |
 Children and adult | 2 | 2.83 (1.29–6.21) | 0.010 | 95.3% |
Publication year | ||||
 Recent 5 years | 5 | 2.42 (1.45–4.02) | 0.001 | 95.5% |
 Over 5 years | 3 | 2.84 (1.85–4.37) | 0.000 | 88.1% |
Study duration | ||||
 10 years | 3 | 2.94 (1.91–4.52) | 0.000 | 88.3% |
 4 years | 2 | 1.76 (0.31–9.92) | 0.522 | 98.4% |
The risk of RA in CD | 6 | 3.14 (2.46–4.01) | 0.000 | 74.9% |
Study design | ||||
 Cross-sectional | 4 | 2.71 (2.14–3.42) | 0.000 | 70.9% |
 Retrospective cohort | 2 | 4.37 (2.84–6.73) | 0.000 | 38.8% |
Age | ||||
 Children | 1 | 15.70 (4.60–53.70) | 0.000 | – |
 Adult | 3 | 9.59 (3.86–23.83) | 0.000 | 51.0% |
 Children and adult | 2 | 3.64 (1.66–8.00) | 0.001 | 84.6% |
Publication year | ||||
 Recent 5 years | 2 | 4.37 (2.84–6.73) | 0.000 | 38.8% |
 Over 5 years | 4 | 3.17 (2.05–4.90) | 0.000 | 75.1% |
The risk of RA in UC | 5 | 2.29 (1.76–2.97) | 0.000 | 84.7% |
Study design | ||||
 Cross-sectional | 4 | 2.15 (1.62–2.86) | 0.000 | 83.6% |
 Retrospective cohort | 2 | 2.55 (1.11–5.87) | 0.000 | 92.8% |
Age | ||||
 Children | 1 | 3.60 (0.80–16.10) | 0.094 | – |
 Adult | 3 | 2.22 (1.74–2.84) | 0.000 | 81.4% |
 Children and adult | 2 | 2.41 (0.94–6.14) | 0.066 | 95.4% |
Publication year | ||||
 Recent 5 years | 2 | 2.55 (1.11–5.87) | 0.027 | 92.8% |
 Over 5 years | 4 | 2.15 (1.62–2.86) | 0.000 | 83.6% |