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Table 3 Subgroup analysis on the risk of RA in IBD

From: The risk of rheumatoid arthritis among patients with inflammatory bowel disease: a systematic review and meta-analysis

Subgroup analysis No. of
Studies
Pooled estimates (random-effects model)
Relative risk (95% CI) P value I2 statistics
The risk of RA in IBD 8 2.59 (1.93–3.48) 0.000 94.2%
Study design
 Cross-sectional 3 2.84 (1.85–4.37) 0.000 88.1%
 Case-control 2 1.62 (0.32–8.07) 0.557 92.9%
 Retrospective cohort 3 3.16 (2.26–4.41) 0.000 89.4%
Age
 Children 1 9.60 (3.90–23.80) 0.000
 Adult 5 2.20 (1.53–3.17) 0.000 95.6%
 Children and adult 2 2.83 (1.29–6.21) 0.010 95.3%
Publication year
 Recent 5 years 5 2.42 (1.45–4.02) 0.001 95.5%
 Over 5 years 3 2.84 (1.85–4.37) 0.000 88.1%
Study duration
 10 years 3 2.94 (1.91–4.52) 0.000 88.3%
 4 years 2 1.76 (0.31–9.92) 0.522 98.4%
The risk of RA in CD 6 3.14 (2.46–4.01) 0.000 74.9%
Study design
 Cross-sectional 4 2.71 (2.14–3.42) 0.000 70.9%
 Retrospective cohort 2 4.37 (2.84–6.73) 0.000 38.8%
Age
 Children 1 15.70 (4.60–53.70) 0.000
 Adult 3 9.59 (3.86–23.83) 0.000 51.0%
 Children and adult 2 3.64 (1.66–8.00) 0.001 84.6%
Publication year
 Recent 5 years 2 4.37 (2.84–6.73) 0.000 38.8%
 Over 5 years 4 3.17 (2.05–4.90) 0.000 75.1%
The risk of RA in UC 5 2.29 (1.76–2.97) 0.000 84.7%
Study design
 Cross-sectional 4 2.15 (1.62–2.86) 0.000 83.6%
 Retrospective cohort 2 2.55 (1.11–5.87) 0.000 92.8%
Age
 Children 1 3.60 (0.80–16.10) 0.094
 Adult 3 2.22 (1.74–2.84) 0.000 81.4%
 Children and adult 2 2.41 (0.94–6.14) 0.066 95.4%
Publication year
 Recent 5 years 2 2.55 (1.11–5.87) 0.027 92.8%
 Over 5 years 4 2.15 (1.62–2.86) 0.000 83.6%
  1. CD Crohn Disease, IBD Inflammatory Bowel Disease, RA Rheumatoid Arthritis, UC Ulcerative Colitis