Skip to main content

Table 2 Characteristics of the included studies-Part II

From: The risk of rheumatoid arthritis among patients with inflammatory bowel disease: a systematic review and meta-analysis

Study Case
type
Sample (size (n)/Age range (years)/Male (%)) Adjusted RR
(95%CI)
Covariates adjustment NOS
score
Cases Controls
Aletaha-2019 [17] IBD 68,535/18–64/NM 42,371,769/18–64/NM 3.5 (3.3–3.8) Age, sex, region, and insurance 7
Bae-2017 [14] IBD 40,843/All/60.2 122,529/All/60.2 3.41 (2.61–4.44) Age, sex, and insurance 7
CD 12,646/All/69.1 3.74 (2.47–5.65)
UC 28,197/All/59.2 3.31 (2.49–4.40)
Burisch-2019 [16] IBD 11,777/≥18/NM 1 for 5 matcheda
/≥18/NM
2.11 (1.66–2.67) Age, sex 8
CD NM/≥18/NM 3.59 (2.32–5.54)
UC NM/≥18/NM 1.67 (1.21–2.30)
Cohen-2008-1 [13] IBD 18,603/≥18/44.3 66,969/≥18/44.3 2.72 (2.43–3.04) Age, sex, region, and insurance 7
CD 9267/≥18/43.0 37,068/≥18/43.0 2.76 (2.40–3.18)
UC 11,220/≥18/46.0 44,880/≥18/46.0 2.76 (2.40–3.18)
Cohen-2008-2 [13] IBD 16,139/≥18/45.5 64,556/≥18/45.5 2.05 (1.84–2.29) Age, sex, region, and insurance 7
CD 7404/≥18/42.7 29,604/≥18/42.7 2.37 (2.02–2.77)
UC 10,104/≥18/45.7 40,416/≥18/45.7 2.16 (1.88–2.49)
Halling-2017 [12] IBD 47,325/All/46 92,839/All/46 1.8 (1.5–2.0) Age, sex, and region 8
CD 13,343/All/42 26,172/All/42 2.1 (1.6–2.8)
UC 31,066/All/47 60,951/All/47 1.6 (1.3–1.9)
Kappelman-2011 [11] IBD 1242/≤20/55 3353/≤20/54 9.6 (3.9–23.8) Age, sex, and region 8
CD 737/≤20/56 1997/≤20/56 15.7 (4.6–53.7)
UC 488/≤20/53 1310/≤20/52 3.6 (0.8–16.1)
Park-2019 [15] IBD 35,581/≤80/61.6 142,324/≤80/61.6 4.24 (3.25–5.52) Age, sex 8
CD 11,803/≤80/70.9 47,212/≤80/70.9 5.59 (3.32–9.41)
UC 23,737/≤80/56.9 94,948/≤80/56.9 3.90 (2.86–5.32)
Puolakka-2014 [19] RA 7209/≥17/32 NM/NM/NM 0.74 (0.51–1.03) Age, sex 7
Kronzer-2019 [18] RA 821/≥18/27 2455/≥18/27 3.82 (1.77–8.41) Age, sex, region, race, BMI, education, smoking, CCI 6
Weng-2007 [10] IBD 12,601/≤89/47.5 50,404/≤89/47.5 1.9 (1.5–2.3) Age, sex, insurance, and smoking 9
CD 4021/≤89/44.1 1 for 4 matched/≤89/44.1 2.5 (1.8–3.5)
UC 7525/≤89/49.3 1 for 4 matched/≤89/49.3 1.5 (1.2–2.0)
Yang-2018 [9] IBD 43,281/19–75/70.1 1,127,261/19–75/48.4 1.60 (1.52–1.68) No 6
CD 13,925/19–75/63.5 1.47 (1.34–1.61)
UC 29,356/19–75/57.6 1.67 (1.57–1.77)
  1. BMI Body Mass Index, CCI Charlson Comorbidity Index, CD Crohn Disease, IBD Inflammatory Bowel Diseases, RA Rheumatoid Arthritis, RR Relative Risk, UC Ulcerative Colitis
  2. aThe sample size of CD and UC was not mentioned; however, each patient was paired with 5 age- and sex-matched 5 individuals from the general population