|
Study factors
|
Subgroups
|
Case (n)
|
Sensitivity (95% CI)
|
I2 (%)
|
Specificity (95% CI)
|
I2 (%)
|
PLR (95% CI)
|
NLR (95% CI)
|
DOR (95% CI)
|
AUROC (95% CI)
|
|---|
|
Geographic region
|
Asian
|
11
|
0.64 (0.49, 0.77)
|
96.08
|
0.76 (0.65, 0.85)
|
92.08
|
2.7 (1.9, 3.7)
|
0.47 (0.34, 0.65)
|
6 (3, 9)
|
0.77 (0.73, 0.80)
|
|
Non-Asian
|
16
|
0.77 (0.71, 0.83)
|
81.33
|
0.83 (0.76, 0.88)
|
76.03
|
4.5 (3.2, 6.5)
|
0.27 (0.20, 0.37)
|
17 (9, 30)
|
0.87 (0.84, 0.90)
|
|
Type of disease
|
NASH
|
13
|
0.74 (0.66, 0.81)
|
74.94
|
0.85 (0.77, 0.91)
|
79.60
|
5.0 (3.1, 8.0)
|
0.31 (0.23, 0.42)
|
16 (8, 32)
|
0.86 (0.83, 0.89)
|
|
NAFLD
|
14
|
0.71 (0.58, 0.81)
|
96.88
|
0.76 (0.68, 0.83)
|
90.57
|
3.0 (2.2, 4.0)
|
0.38 (0.26, 0.55)
|
8 (5, 13)
|
0.80 (0.77, 0.84)
|
|
Regulation mode
|
Upregulation
|
21
|
0.74 (0.65, 0.81)
|
95.92
|
0.78 (0.71, 0.83)
|
90.07
|
3.4 (2.5, 4.6)
|
0.33 (0.24, 0.46)
|
10 (6, 17)
|
0.83 (0.80, 0.86)
|
|
Downregulation
|
6
|
0.66 (0.56, 0.74)
|
59.82
|
0.89 (0.79, 0.95)
|
58.87
|
6.0 (3.2, 11.5)
|
0.38 (0.30, 0.49)
|
16 (8, 31)
|
0.83 (0.79, 0.86)
|
|
Proportion of males
|
≥ 50%
|
12
|
0.64 (0.50, 0.76)
|
95.58
|
0.74 (0.63, 0.82)
|
90.78
|
2.4 (1.8, 3.2)
|
0.49 (0.37, 0.65)
|
5 (3, 8)
|
0.75 (0.71, 0.79)
|
|
< 50%
|
9
|
0.77 (0.66, 0.85)
|
81.17
|
0.87 (0.76, 0.93)
|
58.46
|
5.7 (3.3, 10.0)
|
0.27 (0.19, 0.39)
|
21 (11, 31)
|
0.89 (0.86, 0.90)
|
|
BMI
|
≥ 30 kg/m2
|
15
|
0.77 (0.69, 0.83)
|
82.34
|
0.84 (0.76, 0.89)
|
76.67
|
4.7 (3.2, 6.9)
|
0.28 (0.20, 0.38)
|
17 (9, 31)
|
0.87 (0.84, 0.90)
|
|
< 30 kg/m2
|
9
|
0.63 (0.45, 0.78)
|
96.69
|
0.75 (0.61, 0.85)
|
93.11
|
2.5 (1.8, 3.6)
|
0.49 (0.34, 0.71)
|
5 (3, 9)
|
0.76 (0.72, 0.79)
|
- AUROC area under the receiver operating characteristic curve, CI confidence interval, DOR diagnostic odds ratio, NAFLD nonalcoholic fatty liver disease, NASH nonalcoholic steatohepatitis, NLR negative likelihood ratio, PLR positive likelihood ratio
