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Table 2 Predictors of overall survival from DEB-TACE-1 (period t0) with pre-DEB-TACE variables (n = 216) based on multivariate Cox regression

From: The development of early ascites is associated with shorter overall survival in patients with hepatocellular carcinoma treated with drug-eluting embolic chemoembolization

T0  Univariate analysisMultivariate analysis
VariableCategoriesn = 216Overall survival (months)p-valueHRHR 95% CIp-value
medianmedian 95% CI
Esophageal varicesNo varices723022.7–37.20.025   
Varices1312521.2–28.8
>  3 nodulesNo1802723.8–30.20.029   
Yes332318.6–27.4
Tumor sizeb(mm)<  36.51283026.9–33.10.0250.720.53–0.980.039
>  36.5842217.5–26.5
AFP pre-TACE a (ng/mL)<  12.81053025.8–34.20.008   
>  12.81052319.2–26.8
AFP pre-TACE (ng/mL)< 1001652926.1–31.80.0090.670.47–0.960.029
> 100441813.4–22.6
AFP pre-TACE (ng/mL)< 2001812926.5–31.5< 0.001   
> 200281511.1–18.9
AFP pre-TACE (ng/mL)< 4001922825.2–30.80.002   
> 40017138.2–17.8
Bil pre-TACE a (mg/dL)<  11302824.2–31.80.052   
>  1792521.3–28.7
Bil pre-TACE (mg/dL)<  21912723.8–30.10.47   
>  2172723.1–30.9
Alb pre-TACE a (g/L)<  401102420.3–27.30.112   
>  40982824.34–31.6
Alb pre-TACE (g/L)<  35392318.6–27.40.021   
> 351692925.9–32.04
AP preTACEa(IU/L)<  1081053228.01–35.9< 0.0010.640.47–0.880.005
>  1081052420.8–27.2
Hb pre-TACEa (g/dL)<  13.61082419.02–28.90.155   
>  13.61052825.6–30.3
Platelets preTACE, 10^9 / L<  100902622.3–29.60.93   
> 1001212722.7–31.2
Ascites preTACENo1982724.4–29.60.068   
Yes182116.9–25.01
CSPHNo593022.5–37.50.045   
Yes1572622.3–29.7
  1. CI Confidence interval, HR Hazard ratio, TACE Transarterial chemoembolization, BCLC Barcelona Clinic Liver Cancer, CSPH Clinically significant portal hypertension., AFP Alpha-fetoprotein, Bil Bilirubin, Alb Albumin, AP Alkaline phosphatase, Hb Hemoglobin
  2. aThe median values were used as a cut-off for continuous variables. b Tumor size estimated by AUROC
  3. Other variables evaluated: sex (p = 0.156), etiology (0.197); diabetes (p = 0.929); AST (p = 0.340); ALT (p = 0.791); GGT (p = 0.289); Creatinine (p = 0.847); Na (p = 0.944); CBCT use (p = 0.495); DEB size (p = 0.283)