Fig. 1

Differential expression of circulating miRNAs in pancreatic lesions compared to chronic pancreatitis. a-b-c-d Volcano plots of miRNAs expression showing significant (P < 0.05) and deregulated (with a |LinearFC| > 1.5) miRNAs in each comparison. e-f-g-h-i-j-k NanoString results were validated by qRT-PCR analysis. The expression levels of the indicated miRNAs in the CP group (here considered as a control group) were compared with the expression of the same miRNAs within the indicated pancreatic cancer groups. The square inside the box plot indicates the mean value, whereas the “x” outside the box indicates the 99-percentile. Student’s t-test was performed for statistical analysis. *, 0.01 < P ≤ 0.05; **, 0.001 < P ≤ 0.01