Table 4 Phospho- and sphingolipids (ng/μl) of hereditary hemochromatosis (HH) group stratified by PNPLA3 genotype. Serum samples were quantified in ng/μl serum. Mean ± SD or median (IQR) are shown with p-values for the group differences based on Welch’s t-test (a) or Mann-Whitney U test (b)
From: Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis
CC n = 26 | CG/GG n = 28 | p-value | ||
|---|---|---|---|---|
Phospholipids | ||||
PC | Saturated | 753.7 ± 37.6 | 747.8 ± 23.0 | 0.50a |
MUFA | 2524.5 ± 1078.8 | 2292.3 ± 880.0 | 0.40a | |
PUFA | 8352.1 2 ± 467.5 | 7688.1 ± 2206.7 | 0.31a | |
Alkyl | 619.1 ± 204.9 | 619.4 ± 205.3 | 0.99a | |
Total | 12,249.3 ± 3624.0 | 11,347.7 ± 3066.5 | 0.34a | |
LPC | Saturated | 54.0 ± 12.4 | 59.5 ± 16.0 | 0.17a |
MUFA | 10.2 ± 2.5 | 10.8 ± 2.9 | 0.44a | |
PUFA | 15.8 ± 4.0 | 16.6 ± 4.5 | 0.52a | |
Total | 80.0 ± 16.5 | 86.8 ± 21.9 | 0.21a | |
PI | MUFA | 18.80 ± 9.5 | 20.5 ± 10.5 | 0.55a |
PUFA | 155.1 ± 57.6 | 173.9 ± 63.7 | 0.26a | |
Total | 173.9 ± 64.9 | 194.3 ± 72.4 | 0.28a | |
PS | MUFA | 3.2 (5.1) | 0.0 (2.6) | 0.16b |
PUFA | 24.6 (98.3) | 23.4 (39.4) | 0.55b | |
Total | 27.2 (104.1) | 23.6 (49.9) | 0.43b | |
PE | MUFA | 85.7 (363.4) | 92.8 (271.3) | 0.99b |
PUFA | 279.1 (236.7) | 302.5 (278.7) | 0.48b | |
total | 370.9 (607.0) | 409.1 (545.4) | 0.64b | |
LPE | Saturated | 1.3 (0.8) | 1.3 (0.8) | 0.94b |
MUFA | 0.4 (1.1) | 0.6 (0.9) | 0.46b | |
PUFA | 2.4 (4.7) | 2.2 (2.5) | 0.76b | |
Total | 3.9 (5.1) | 4.6 (4.5) | 0.78b | |
Sphingolipids | ||||
SM | Saturated | 892.4 ± 269.5 | 861.6 ± 292.2 | 0.69a |
MUFA | 3074.6 ± 1122.1 | 2705.7 ± 1210.4 | 0.26a | |
PUFA | 1702.8 ± 409.3 | 1751.3 ± 359.3 | 0.65a | |
Alkyl | 461.2 ± 228.5 | 469.10 ± 248.0 | 0.90a | |
Total | 6130.94 ± 1688.2 | 5787.7 ± 1806.0 | 0.48a | |
Ratio PC/PE | 23.1 | 21.4 | ||