Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis

BMC Gastroenterology

Table 3 PNPLA3 genotype CC vs. CG/GG of hereditary hemochromatosis (HH) group. Mean ± SD or median (IQR) or frequencies n (%) are shown with p-values for the group differences based on Welch’s t-test (a), Mann-Whitney U test (b) or chi-square test (c)

	limits of normal	CC n = 26	CG/GG n = 28	p-value
Cholesterol	mg/dl	181.6 ± 35.2	193.9 ± 40.8	0.26^a
HDL	> 40 mg/dl	58.8 ± 20.4	51.1 ± 18.1	0.18^a
LDL	< 160 mg/dl	105.8 ± 22.7	116.3 ± 29.3	0.20^a
Triglycerides	< 150 mg/dl	97.0 (58.8)	128.5 (125.0)	0.17^b
Ferritin	μg/l	153.5 (465.5)	562.0 (1064.5)	0.18^b
Transferrin	2.0–3.6 g/l	1.9 ± 0.3	1.8 ± 0.3	0.40^a
TS	16–45%	73.8 ± 22.8	68.4 ± 26.7	0.44^a
Iron	14–32 μmol/l	33.1 ± 9.2	30.6 ± 11.1	0.34^a
Albumin	30–50 g/l	44.7 ± 2.7	44.9 ± 2.6	0.79^a
Bilirubin	< 1.0 mg/dl	0.6 (0.5)	0.8 (0.7)	0.20^b
GGT	< 60 U/l	23.0 (39.5)	26.0 (25.3)	0.94^b
AST	< 46 U/l	25.0 (15.0)	35.5 (20.3)	0.04^b
ALT	< 50 U/l	23.5 (10.5)	31.5 (16.5)	0.19^b
BMI	kg/m²	26.4 ± 3.9	25.7 ± 2.7	0.44^a
FibroScan	< 6 kPa	6.8 ± 5.4	6.5 ± 4.1	0.79^a
Hepatic steatosis	none	9 (34.6%)	7 (25%)	0.62^c
	mild	9 (34.6%)	9 (32.1%)
	moderate	4 (15.4%)	8 (28.6%)
	severe	3 (3.8%)	2 (7.1%)

ALT alanine aminotransferase; AST aspartate aminotransferase; BMI body mass index; HDL high-density lipoprotein; IQR interquartile range; LDL low-density lipoprotein; PNPLA3. human patatin like phospholipase domain-containing 3; SD standard deviation; TS transferrin saturation;

ISSN: 1471-230X