The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis

Table 6 univariate and multivariate analysis for the entire patients with locally advanced gastric cancer

	Univariate analysis			^aMultivariate analysis			^bMultivariate analysis
Variables	HR	95%CI	p	HR	95%CI	p	HR	95%CI	p
Gender (female)	0.857	0.584–1.258	0.431
Age (> 60 years)	1.067	0.764–1.489	0.705
Lauren classification			0.032			0.245			0.132
Intestinal	1			1			1
Diffused	1.658	1.128–2.437		1.363	0.853–2.179		1.431	0.886–2.309
Mixed	1.45	0.94–2.237		0.961	0.581–1.589		0.929	0.568–1.519
Nerve invasion (yes)	1.675	1.094–2.51	0.017	1.098	0.633–1.903	0.74	1.068	0.612–1.863	0.816
Vessel invasion (yes)	2.07	1.228–3.487	0.006	1.008	0.505–2.01	0.983	1.102	0.555–2.191	0.781
Tumor location			0.916
Upper	1
Middle	0.979	0.634
Lower	1.062	0.67–1.682
Differentiation degree (well)	0.638	0.455–0.895	0.009	0.747	0.487–1.144	0.18	0.74	0.481–1.138	0.17
Tumor size (> 4 cm)	1.891	1.353–2.644	< 0.001	1.371	0.961–1.956	0.082	1.293	0.899–1.859	0.166
CEA (> 3.4 ng/ml)	1.507	1.081–2.102	0.016	1.097	0.75–1.604	0.632
CEA (> 7.2 ng/ml)							1.4	0.919–2.132	0.117
CA199 (> 37 U/ml)	2.089	1.4–3.116	< 0.001	1.608	1.051–2.46	0.028	1.492	0.978–2.274	0.063
CA125 (> 35 U/ml)	1.776	0.933–3.382	0.08	1.223	0.632–2.369	0.55	1.038	0.519–2.078	0.915
LNM based on pathology (yes)	4.758	2.896–7.816	< 0.001	3.661	2.079–6.446	0.001	3.38	1.937–5.898	0.001
pT stage			< 0.001			0.04			0.074
T2	1			1			1
T3	2.627	1.008–6.843		1.163	0.414–3.266		1.123	0.4–3.154
T4	5.682	2.314–13.951		2.021	0.727–5.617		3.38	1.937–5.898

ISSN: 1471-230X