Fig. 2

Dynamic adhesion of CD4⁺ T cells to MAdCAM-1 in the cohort of 21 UC patients. a Representative dynamic adhesion assays from a responder (left) and a non-responder (right) to vedolizumab treatment. Overlay images from the beginning and the end of the collected time-lapse sequences with enumeration of adhering cells (white, some of them highlighted with yellow arrows) are shown. Scale bar – 50 μm. b Dynamic adhesion of CD4⁺ T cells to MAdCAM-1 in responders (n = 12) vs. non-responders (n = 9). Statistical comparison with two-tailed Mann-Whitney test. c Receiver-operator characteristic (ROC) analysis of the dynamic adhesion of CD4⁺ T cells to MAdCAM-1 in responders vs. non-responders. The p-value is indicated. d Reduction of dynamic adhesion of CD4⁺ T cells to MAdCAM-1 after vedolizumab treatment in vitro in responders (n = 12) vs. non-responders (n = 9). Statistical comparison with two-tailed Mann-Whitney test. e Receiver-operator characteristic (ROC) analysis of the reduction of dynamic adhesion of CD4⁺ T cells to MAdCAM-1 after vedolizumab treatment in vitro in responders vs. non-responders. The p-value is indicated