Table 5 Association between 5 SNPs and expression of LATS1 and LATS2 under different genetic models
From: Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer
Locus | Model | Genotype | Positive expression N(%) | Negative expression N(%) | OR (95% CI)a | P | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
LATS1 rs9393175 | codominant | G/G | 30 (62.50) | 40 (65.57) | 1 | – | 157.896 | 171.353 |
A/G | 15 (31.25) | 16 (26.23) | 1.208 (0.508–2.869) | 0.667 | ||||
A/A | 3 (6.25%) | 5 (8.20) | 0.795 (0.152–3.535) | 0.767 | ||||
dominant | G/G | 30 (62.50) | 40 (65.57) | 1 | – | 156.162 | 166.927 | |
A/A + A/G | 18 (37.50) | 21 (34.43) | 1.110 (0.497–2.467) | 0.798 | ||||
recessive | G/G + A/G | 45 (93.75) | 56 (91.80) | 1 | – | 156.082 | 166.847 | |
A/A | 3 (6.25) | 5 (8.20) | 0.750 (0.146–3.258) | 0.706 | ||||
overdominant | G/G + A/A | 33 (68.75) | 45 (73.77) | 1 | – | 155.985 | 166.751 | |
A/G | 15 (31.25) | 16 (26.23) | 1.237 (0.527–2.897) | 0.623 | ||||
log-additive | – | – | – | 1.012 (0.544–1.863) | 0.970 | 156.225 | 166.991 | |
LATS2 rs558614 | codominant | T/T | 20 (26.67) | 6 (17.14) | 1 | – | 144.846 | 158.348 |
C/T | 35 (46.67) | 21 (60.00) | 0.505 (0.163–1.407) | 0.208 | ||||
C/C | 20 (26.67) | 8 (22.86) | 0.739 (0.208–2.522) | 0.630 | ||||
dominant | T/T | 20 (26.67) | 6 (17.14) | 1 | – | 143.431 | 154.233 | |
T/C + C/C | 55 (73.33) | 29 (82.86) | 0.570 (0.190–1.513) | 0.280 | ||||
recessive | T/T + C/T | 55 (73.33) | 27 (77.14) | 1 | – | 144.519 | 155.321 | |
C/C | 20 (26.67) | 8 (22.86) | 1.200 (0.478–3.229) | 0.705 | ||||
overdominant | C/C + T/T | 40 (53.33) | 14 (40.00) | 1 | – | 143.079 | 153.881 | |
C/T | 35 (46.67) | 21 (60.00) | 0.593 (0.258–1.336) | 0.211 | ||||
log-additive | – | – | – | 0.882 (0.491–1.572) | 0.670 | 144.483 | 155.285 | |
LATS2 rs9552315 | codominant | T/T | 25 (33.33) | 7 (20.59) | 1 | – | 141.158 | 154.615 |
C/T | 31 (41.33) | 20 (58.82) | 0.409 (0.139–1.100) | 0.087 | ||||
C/C | 19 (25.33) | 7 (20.59) | 0.716 (0.207–2.451) | 0.591 | ||||
dominant | T/T | 25 (33.33) | 7 (20.59) | 1 | – | 140.308 | 151.073 | |
T/C + C/C | 50 (66.67) | 27 (79.41) | 0.489 (0.174–1.244) | 0.149 | ||||
recessive | T/T + C/T | 56 (74.67) | 27 (79.41) | 1 | – | 142.279 | 153.044 | |
C/C | 19 (25.33) | 7 (20.59) | 1.283 (0.493–3.632) | 0.621 | ||||
overdominant | C/C + T/T | 44 (58.67) | 14 (41.18) | 1 | – | 139.447 | 150.213 | |
C/T | 31 (41.33) | 20 (58.82) | 0.478 (0.205–1.089) | 0.082 | ||||
log-additive | – | – | – | 0.836 (0.473–1.468) | 0.533 | 142.140 | 152.905 | |
LATS2 rs7317471 | C/C | 63 (85.14) | 26 (74.29) | 1 | – | 142.226 | 152.992 | |
C/T | 11 (14.86) | 9 (25.71) | 0.509 (0.186–1.413) | 0.187 | ||||
LATS2 rs9509492 | codominant | A/A | 34 (45.33) | 16 (44.44) | 1 | – | 147.894 | 161.441 |
A/G | 32 (42.67) | 18 (50.00) | 0.842 (0.364–1.936) | 0.686 | ||||
G/G | 9 (12.00) | 2 (5.56) | 2.138 (0.478–15.146) | 0.366 | ||||
dominant | A/A | 34 (45.33) | 16 (44.44) | 1 | – | 147.305 | 158.143 | |
A/G + G/G | 41 (54.67) | 20 (55.56) | 0.972 (0.433–2.167) | 0.945 | ||||
recessive | A/A + A/G | 66 (88.00) | 34 (94.44) | – | 146.058 | 156.896 | ||
G/G | 9 (12.00) | 2 (5.56) | 2.332 (0.559–15.911) | 0.297 | ||||
overdominant | A/A + G/G | 43 (57.33) | 18 (50.00) | 1 | – | 146.805 | 157.644 | |
A/G | 32 (42.67) | 18 (50.00) | 0.748 (0.334–1.670) | 0.478 | ||||
log-additive | – | – | – | 1.147 (0.623–2.160) | 0.662 | 147.118 | 157.956 |