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Fig. 1 | BMC Gastroenterology

Fig. 1

From: 25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor

Fig. 1

Vitamin D alleviates hepatic fibrosis in acute model of CCl4 while worsen in the chronic model. a. Liver histology assessments showed that vitamin D IP administration (0.5 mg/100 g body weight) caused a lack of hepatic fibrosis following staining with by the Trichrome and Sirius red in the 1 week injections of CCl4 (acute model) while aggravate collagen formations in the 4 weeks of CCl4 (chronic model). b. Serum ALT levels were significantly (P = 0.04) increased in the acute and chronic models of CCl4 and a further increased in ALT were seen following vitamin D treatments only in the chronic model (p = 0.04). Liver primary hepatic stellate cells (c.) RNA αSMA quantitation by RT PCR and western blot protein quantitation of (d.) αSMA and (e.) Collagen showed similar patterns to histology assessments

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