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Table 2 Characteristics of elderly groups with advanced fibrosis (F3–4) vs. non-advanced fibrosis (F0–2)

From: Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: the GOASIA study

Elderly NAFLD

Non-advanced fibrosis

Advanced fibrosis

P-value

Characteristics, median (IQR); n (%)

(n = 113)

(n = 62)

Age (year)

64 (62–66)

65 (62–68)

0.118

Female

57 (50.4%)

45 (72.6%)

0.005

Weight (kg)

68.35 (59.88–78.00)

70.7 (64–79)

0.565

Height (m)

1.6 (1.57–1.70)

1.6 (1.54–1.68)

0.227

BMI (kg/m2)

26.68 (23.94–29.12)

27.55 (25.89–31.22)

0.055

BMI ≥ 25 (kg/m2)

74 (65.5%)

52 (83.9%)

0.01

Waist circumference (cm)

92.05 (84–100)

96 (89.50–102.50)

0.017

Hip circumference (cm)

98 (92.00–104.63)

101 (95.50–109)

0.158

Central obesity

72 (79.1%)

54 (94.7%)

0.009

Diabetes

73 (64.6%)

49 (79.0%)

0.047

Hypertension

69 (67%)

53 (88.3%)

0.002

Dyslipidemia

94 (83.2%)

54 (87.1%)

0.493

Albumin (g/L)

43 (42–45)

43 (40–46)

0.637

ALT (U/L)

52.5 (37–89.75)

66 (36–91)

0.276

AST (U/L)

38.5 (27.25–56.75)

51 (34–82)

0.086

ALP (U/L)

63 (49–117.25)

69.5 (69–70)

0.615

GGT (U/L)

48 (34.25–70.75)

75 (42.75–122.5)

0.002

HbA1c (%)

6.5 (5.9–7.4)

6.7 (6.13–7.28)

0.435

Total cholesterol (mmol/L)

4.4 (3.5–5.38)

4.35 (3.53–5.1)

0.483

LDL cholesterol (mmol/L)

2.32 (1.8–3.23)

2.23 (1.7–3.08)

0.389

HDL cholesterol (mmol/L)

1.2 (1.03–1.4)

1.3 (1.1–1.5)

0.068

Triglycerides (mmol/L)

1.4 (1.2–1.79)

1.5 (1.13–1.8)

0.833

Hemoglobin (g/dL)

14.1 (13.4–14.8)

13.45 (12.63–14.68)

0.055

Platelet (109/L)

229.5 (193–284.25)

205 (145.75–243.25)

0.003

WBC (109/L)

7 (5.8–8.23)

6.9 (5.83–8.15)

0.638

NAFLD Activity Score (NAS)

4 (3–5)

4 (4–5)

0.023

NAS ≥ 5

32 (28.3%)

26 (41.9%)

0.067

Platelet count < 140 × 109/L

10 (8.8%)

13 (21%)

0.023

NAFL fibrosis score (NFS)a

−1.00 (1.48)

−0.24 (1.4)

0.005

APRI scorea

0.91 (1.41)

1.74 (2.85)

0.077

FIB-4 scorea

3.06 (5.15)

5.57 (9.01)

0.095

  1. APRI AST to platelet ratio index, BMI body mass index; Non-Alcoholic Steatohepatitis (NAS) score
  2. amean (SD)