Table 8 Neutropenia compared withUGT1A1wild-type、single-point and double-point mutants (%)
Genotype | Total n | neutropenia n(%) | X2 | P | |
|---|---|---|---|---|---|
UGT1A1*28 | 0~II | III~IV | 2.844 | 0.139 | |
6/6 | 60 | 51 (85.0) | 9 (15.0) | ||
6/7 | 26 | 18 (69.2) | 8 (30.8) | ||
UGT1A1*6 | 5.727 | 0.027 | |||
G/G | 66 | 56 (84.8) | 10 (15.2) | ||
G/A + A/A | 20 | 12 (60.0) | 8 (40.0) | ||
Numbers of mutational alleles | 23.171 | 0.000 | |||
Double single type | 53 | 50 (94.3) | 3 (5.7) | ||
Single variant | 22 | 13 (59.1) | 9 (40.9) | ||
Double variant | 11 | 4 (36.4) | 7 (63.6) | ||