Table 12 Toxicity with irinotecan dose reduction and UGT1A1 status (%)
Toxicity | UGT1A1*28 | UGT1A1*6 | ||
|---|---|---|---|---|
Dose reduction | Non-dose reduction | Dose reduction | Non-dose reduction | |
Diarrhea | ||||
 0 grade | 6 (40.0) | 47 (66.2) | 8 (53.3) | 45 (63.4) |
 1–2 grade | 9 (60.0) | 21 (29.6) | 6 (40.0) | 24 (33.8) |
 3–4 grade | 0 (0.0) | 3 (4.2) | 1 (6.7) | 2 (2.8) |
Neutropenia | ||||
 0 grade | 9 (60.0) | 45 (63.4) | 9 (60.0) | 48 (67.6) |
 1–2 grade | 5 (33.3) | 21 (29.6) | 4 (26.7) | 21 (29.6) |
 3–4 grade | 1 (6.7) | 5 (7.0) | 2 (13.3) | 2 (2.8) |