Table 4 Univariate and multivariate analysis of overall survival in PDAC patients with T2DM
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age (years) (> 60 versus ≤60) | 1.099 (0.826–1.462) | 0.519 | ||
Gender (Male versus Female) | 1.289 (0.963–1.725) | 0.087 | 1.083 (0.795–1.476) | 0.614 |
BMI (kg/m2) | 0.973 (0.927–1.022) | 0.278 | ||
Smoking status (Yes versus No) | 1.052 (0.770–1.436) | 0.750 | ||
Drinking status (Yes versus No) | 1.076 (0.766–1.513) | 0.672 | ||
FPG (mmol/L) (log-value) | 1.165 (0.792–1.713) | 0.439 | ||
Albumin (g/L) | 1.013 (0.989–1.037) | 0.283 | ||
Hemoglobin (g/dl) | 0.998 (0.989–1.008) | 0.706 | ||
WBC (×109/L) | 1.053 (1.002–1.106) | 0.043 | 1.032 (0.979–1.087) | 0.241 |
Platelet count (× 109/L) | 1.000 (0.999–1.002) | 0.629 | ||
MPV (fL) (≤ 10.0 versus > 10.0) | 1.914 (1.414–2.592) | < 0.001 | 1.801 (1.305–2.485) | < 0.001 |
CA19–9 (IU/mL) | ||||
(≤ 37 versus > 37) | 1.205 (0.903–1.609) | 0.205 | 1.856 (1.122–3.070) | 0.016 |
Tumor location | ||||
(Head versus Body, tail) | 1.053 (0.779–1.424) | 0.736 | ||
Tumor differentiation | ||||
(Poor versus Well/ moderate) | 2.014 (1.473–2.753) | < 0.001 | 1.180 (0.673–2.070) | 0.563 |
Tumor size (cm) | ||||
(> 4 versus ≤4) | 1.460 (1.091–1.955) | 0.011 | 1.385 (0.832–2.303) | 0.210 |
Regional lymph node metastasis | ||||
(N1 + N2 versus N0) | 1.481 (1.105–1.983) | 0.009 | 1.268 (0.944–1.704) | 0.115 |
Chemotherapy (Yes versus No) | 0.166 (0.119–0.232) | < 0.001 | 0.183 (0.128–0.261) | < 0.001 |