Table 3 Univariate and multivariate analysis of overall survival in PDAC patients without T2DM
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age (years) (> 60 versus ≤60) | 1.139 (0.967–1.343) | 0.120 | ||
Gender (Male versus Female) | 1.022 (0.864–1.207) | 0.802 | ||
BMI (kg/m2) | 0.985 (0.961–1.010) | 0.239 | ||
Smoking status (Yes versus No) | 0.941 (0.792–1.118) | 0.489 | ||
Drinking status (Yes versus No) | 1.001 (0.812–1.234) | 0.993 | ||
FPG (mmol/L) (log-value) | 1.273 (0.750–2.160) | 0.371 | ||
Albumin (g/L) | 1.002 (0.989–1.015) | 0.767 | ||
Hemoglobin (g/dl) | 1.003 (0.998–1.007) | 0.234 | ||
WBC (×109/L) | 0.995 (0.996–1.026) | 0.756 | ||
Platelet count (× 109/L) | 0.999 (0.998–1.000) | 0.071 | 0.999 (0.998–1.001) | 0.131 |
MPV (fL) (≤ 10.0 versus > 10.0) | 1.183 (0.907–1.542) | 0.216 | ||
CA19–9 (IU/mL) | ||||
(≤ 37 versus > 37) | 1.843 (1.488–2.284) | < 0.001 | 1.757 (1.408–2.193) | < 0.001 |
Tumor location | ||||
(Head versus Body, tail) | 1.208 (1.020–1.431) | 0.028 | 1.095 (0.915–1.311) | 0.322 |
Tumor differentiation | ||||
(Poor versus Well/ moderate) | 1.709 (1.324–2.206) | < 0.001 | 1.809 (1.400–2.337) | < 0.001 |
Tumor size (cm) | ||||
(> 4 versus ≤4) | 1.302 (1.051–1.613) | 0.016 | 1.229 (0.992–1.523) | 0.059 |
Regional lymph node metastasis | ||||
(N1 + N2 versus N0) | 1.285 (1.060–1.559) | 0.011 | 1.239 (1.021–1.504) | 0.030 |
Chemotherapy (Yes versus No) | 0.800 (0.679–0.943) | 0.008 | 0.774 (0.654–0.916) | 0.003 |