From: Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies
Authors | Years | Country | Control subjects(selection methods) | Age | Sample size | Type of Diabetic (Mean HbA1C) (Duration of disease) | Measurement of association Odds Ratio (CI 95%) | Controlled variables | Bacteria detection | NOS Score |
---|---|---|---|---|---|---|---|---|---|---|
Małecki, M. et al. [26] | 1996 | Poland | Non-diabetic subjects | 17–80 | 139 (Control:100 & Case: 39) | DM (−) (8 Year) | 0.33 (0.18, 0.59) | – | Histology or biopsy | 6 |
Pocecco, M. et al. [27] | 1997 | Italy | Admitted for minor extra-abdominal surgery with no history of abdominal pain | 16 | 379 [Control:310 & Case: 69] | DM (−) (−) | 3.13 (2.08, 4.70) | Age, sex, education and economic | Rapid urease test | 6 |
Gentile, S [28]. | 1998 | Italy | Non-diabetic subjects | 52 | 328 (Control:164 & Case: 164) | T2DM (8.3 ± 1.4) | 1.77 (1.35, 2.31) | Age, sex and body weight | Histology or biopsy | 7 |
De Luis, DA [29] | 1998 | Spain | The control subjects were healthy volunteers, with similar age and sex-distribution that the diabetic patients | 25 | 180 Control: 100 & Case: 80 | T1DM (−) (3.1 Year) | 1.36 (0.98, 1.87) | Age and sex | Anti-H. pylori antibody | 6 |
Gasbarrini, A.et al. [30] | 1998 | Italy | Healthy subjects | 35 | 166 [Control: 50 & Case: 116] | DM (−) (19 year) | 1.04 (0.85, 1.28) | Age and sex | 13C or 14C urea breath test | 6 |
Salardi, S.et al. [31] | 1999 | Italy | Children with minor endocrine disorders. | 12 | 339 [Control: 236 & Case: 103] | T1DM (−) (−) | 1.47 (0.99, 2.18) | Age | Anti H. pylori antibody | 7 |
Arslan, D. et al. [32] | 2000 | Turkey | Non-diabetic subjects | 12 | 130 (Control: 42 & Case: 88) | T1DM (11.08 ± 3.17) (3.85 Year) | 1.38 (1.08, 1.75) | – | Anti-H. pylori antibody | 6 |
Dore, MP. et al. [33] | 2000 | Italy | Blood donors from the same geographic area | 12–75 | 891 [Control: 506 & Case: 385] | DM (greater than 1 year) | 1.16 (1.00, 1.35) | age and socioeconomic status | Anti-H. pylori antibody | 8 |
Senturk, O. et al. [34] | 2001 | Turkey | Nondiabetic patients undergoing upper diagnostic endoscopies | 54.1 | 140 [Control: 73 & Case: 67] | T2DM (6.42 ± 0.97) (4.5 year) | 1.39 (0.78, 2.48) | Age and socioeconomic | Histology or biopsy | 7 |
Ravera, M.et al. [35] | 2001 | Uganda | Dyspeptic patients without diabetic | – | 132 [Control110: & Case: 22] | DM (−) (−) | 1.22 (0.33, 4.49) | – | Histology or biopsy | 6 |
Ko, G. T.et al. [36] | 2001 | Chine | With upper GI symptoms in whom | 49.9 | 118 [Control55: & Case: 63] | T2DM (8.25 ± 2.22) (6.2 year) | 0.90 (0.64, 1.26) | Age and sex | Rapid urease test | 6 |
Marrollo M.et al. [37] | 2001 | Italy | Non diabetic dyspeptic patients | 63 | 191 [Control: 117& Case: 74] | DM (−) (−) | 1.54 (1.05, 2.27) | Age and sex | Rapid urease test and Histology or biopsy | 6 |
Quatrini, M.et al. [38] | 2001 | Italy | Dyspepsia patients | 58 | 142 [Control: 71 & Case: 71] | DM (−) (−) | 1.63 (1.12, 2.38) | Age and sex | 13C or 14C urea breath test | 7 |
Cenerelli, S. et al. [39] | 2002 | Italy | Control subjects were first selected on the basis of the admission criteria of the senieur protocol. | 55 | 73 Control: 43 & Case: 30) | T2DM (6.1 ± 1.8) (3.1 Year) | 1.04 (0.60, 1.80) | – | 13C or 14C urea breath test | 7 |
Maule, S.et al. [40] | 2002 | Italy | Individuals without diabetes | 46–75 | 62 [Control:31 & Case: 31] | T2DM (7.1 ± 1.4) (−) | 1.65 (0.92, 2.97) | Age | 13C or 14C urea breath test | 8 |
Candelli, M. et al. [41] | 2003 | Italy | The control Group was selected normal healthy adolescent | 17 | 268 Control: 147 & Case: 121) | T1DM (8.2 ± 1.4) (6.7 Year) | 0.97 (0.72, 1.30) | Sex, age and social class | Rapid urease test, Histology or biopsy | 7 |
Gulcelik, N. E.et al. [4] | 2005 | Turkey | Dyspeptic non diabetic subjects | 51.9 | 149 [Control: 71 & Case: 78] | T2DM (8.2 ± 1.4) | 1.92 (1.29, 2.86) | Age and BMI | Histology or biopsy | 7 |
Jaber, S. M.et al. [42] | 2006 | Saudi Arabia | Healthy children | > 10 | 604 [Control:543 & Case: 61] | T1DM (−) (−) | 1.60 (0.98, 2.63) | – | Anti H. pylori antibody | 6 |
Bener, A. et al. [43] | 2007 | Qatar | Non-diabetic subjects | 48 | 420 (Control:210 & Case: 210) | T2DM (6.9 ± 1.4) (−) | 5.03 (3.90, 6.47) | Age and sex | Anti-H. pylori antibody | 7 |
Demir, M. et al. [44] | 2008 | Turkey | The control Subjects were selected in the gastroenterology clinics | 52 | 283 Control: 142 & Case: 141 | T2DM (−) (6 year) | 1.07 (0.84, 1.36) | Age and sex | Rapid urease test and Histology or biopsy | 7 |
Ariizumi, K. et al. [45] | 2008 | Japan | non-diabetic subjects without upper GI tract disorders | 62 | 134 [Control: 67 & Case: 67] | DM (−) (15.1 year) | 0.74 (0.53, 1.03) | age and sex-matched | Anti H. pylori antibody, Rapid urease test, Histology or biopsy | 8 |
Hamed, S. A.et al. [46] | 2008 | Egypt | Subjects with neither history nor clinical evidence of gastrointestinal problems; vascular, inflammatory, or neurologic diseases. | 47.6 | 140 [Control:60 & Case: 80] | DM (−) (9.2 year) | 1.29 (0.83, 2.01) | Age and sex | Anti H. pylori antibody | 8 |
Cabral, V. L. R. et al. [47] | 2009 | Brazil | The control Group was selected normal healthy adolescent | 17 | 45 Control: 30 & Case: 15) | T1DM (−) (−) | 0.52 (0.21, 1.29) | – | Histology or biopsy | 7 |
Lazaraki, G. et al. [48] | 2009 | Greece | non-smoking, non-diabetic with of dyspepsia | 65 | 79 [Control: 30 & Case: 49] | T2DM (−) (3 year) | 0.99 (0.70, 1.40) | Age, sex, H. pylori-infection, degree of gastritis | Rapid urease test and Histology or biopsy | 7 |
Krause, I. et al. [49] | 2009 | Colombia | Individuals had no clinical diabetes, nor islet cell autoantibodies | 16.0 | 180 [Control: 123: & Case: 57] | T1DM (−) (8.8 year) | 0.44 (0.29, 0.66) | – | Anti-H. pylori antibody | 6 |
Devrajani, BR. et al. [15] | 2010 | Pakistan | Non diabetic individuals with positive or negative Helicobacter pylori infection | 53 | 148 [Control: 74 & Case: 74] | T2DM (−) (5 years) | 1.64 (1.11, 2.43) | – | Stool antigen test | 7 |
Ibrahim, A. et al. [50] | 2010 | Egypt | Dyspeptic non diabetic subjects | 45 | 200 [Control: 102 & Case: 98] | T2DM (8.57 ± 0.79) (−) | 0.94 (0.71, 1.25) | – | Rapid urease test, Histology or biopsy | 7 |
El-Eshmawy, M. M. et al. [51] | 2011 | Egypt | Non-diabetic subjects | 20 | 242 (Control:80 & Case: 162) | T1DM (8.2 ± 1.75) (7.29 Year) | 1.63 (1.25, 2.11) | Age, sex, geographic area and socioeconomic status | Anti-H. pylori antibody | 7 |
De Block, C. E. M. et al. [52] | 2012 | Belgium | One-hundred sex- and age-matched controls were tested for H. pylori serology. | 40 | 329 Control: 100 & Case: 229) | T1DM (7.8 ± 1.0) (18 Year) | 0.86 (0.74, 1.02) | Age and sex | Anti-H. pylori antibody & Rapid urease test and Histology or biopsy | 7 |
Candelli, M. et al. [53] | 2012 | Italy | Healthy children | 19.8 | 174 [Control: 99 & Case: 75] | T1DM (8.8 ± 0.80) (−) | 1.96 (1.40, 2.75) | Age, sex and socio-economic | 13C or 14C urea breath test | 6 |
Jafarzadeh, A.et al. [54] | 2012 | Iran | Healthy individuals | 42.86 | 200 [Control: 100 & Case: 100] | T2DM (−) (−) | 1.03 (0.74, 1.42) | Age | Anti H. pylori IgG | 6 |
Keramat, F. et al. [55] | 2013 | Iran | Non-diabetic subjects | 51 | 158 (Control: 79 & Case: 79) | DM (8.96 ± 1.82) (2.78 Year) | 1.29 (0.89, 1.88) | Age and sex | Anti-H. pylori antibody & Rapid urease test and Histology or biopsy | 8 |
Zekry, O. A. et al. [56] | 2013 | Egypt | Healthy children and adolescents | 12.53 | 120 [Control: 60 & Case: 60] | T1DM (7.75 ± 1.67) (9.25 year) | 1.69 (1.21, 2.35) | Age and sex | Anti-H. pylori antibody | 8 |
Chobot, A. et al. [57] | 2014 | Poland | This group was enrolled from a large cohort of children | 13.4 | 447 [Control: 298 & Case: 149] | T1DM (7.69 ± 1.63) (4.6 year) | 0.74 (0.48, 1.15) | Age- and sex | 13C or 14C urea breath test | 8 |
Fayed, SB. et al. [58] | 2014 | Egypt | healthy normal volunteers | 12.2 | 106 [Control:53 & Case: 53] | T1DM (9.6 ± 1.6) (12.2 year) | 1.80 (1.14, 2.84) | Age and sex | Anti H. pylori antibodies | 7 |
Zhou, F. et al. [17] | 2015 | China | Non-diabetic subjects with dyspepsia symptoms | 45 | 253 (Control:65 & Case: 188) | T2DM (8.2 ± 1.9) | 1.15 (0.99, 1.33) | Age and sex | Anti-H. pylori antibody & Rapid urease test | 9 |
Bajaj, S. et al. [3] | 2015 | India | The control group comprised of age, sex, socioeconomic status, and education matched normal healthy volunteers | > 18 | 140 Control: 60 & Case: 80) | T2DM (8.2 ± 1.2) (4.2 Year) | 1.53 (1.04, 2.24) | Age, sex, socioeconomic status, and education | Anti-H. pylori antibody & Rapid urease test and Histology or biopsy | 8 |
Bazmamoun, H. et al. [59] | 2016 | Iran | Non-diabetic subjects | 10 | 160 (Control: 80 & Case: 80) | T1DM (8.00 ± 0.65) (2.72 Year) | 1.50 (1.09, 2.07) | Age, sex, socioeconomic status | Anti-H. pylori antibody | 8 |
Osman, S. M.et al. [60] | 2016 | Sudan | Healthy children | 1–18 | 180 [Control: 90 & Case: 90] | T1DM (−) (6 month) | 0.97 (0.71, 1.33) | age and sex | Anti-H. pylori antibody | 8 |
Alzahrani, S. et al. [61] | 2017 | Saudi Arabia | Non-diabetic subjects | 49 | 842 (Control:421 & Case: 421) | DM (6.1 ± 0.6) | 1.01 (0.88, 1.16) | Age, sex, race, DPP intervention, length of follow-up time, body mass index, alcohol consumption, physical activity and smoking | Anti-H. pylori antibody & Rapid urease test | 9 |
Vaishnav, B. et al. [62] | 2018 | India | Non diabetic with dyspepsia | 56 | 287 [Control: 140 & Case: 147] | T2DM (8.4 ± 1.0) (7.59 year) | 1.89 (1.51, 2.36) | – | Rapid urease test | 8 |