Favourable viral outcomes: | |
 Fully suppressed | HBV DNA undetectable for study period OR HBV DNA became undetectable with no further rise |
 Adequate viral suppression | Where treatment duration was < 2 years, HBV DNA decreased > 1 log10 |
Unfavourable viral outcomes: | |
 Not suppressed | Detectable HBV DNA after 2 years on treatment |
 Non-transient rise | < 1 log rise in HBV DNA which was not a transient rise |
 Viral breakthrough | ≥1x log10 rise in HBV DNA level from nadir which was not a transient rise |
 Transient rise | a single instance of increased DNA level < 150 IU/ML with return to undetectable at next test |