Skip to main content

Table 2 Comparison of clinical characteristics in short-term responders and non-responders to tolvaptan

From: Clinical implications with tolvaptan on monitored bioimpedance-defined fluid status in patients with cirrhotic ascites: an observational study

VariablesRespondersNon-respondersP (uni)
N16 (53%)14 (47%)
Age, years71 [46–87]65 [51–80]0.227
Sex, M/F8/89/50.484
ΔBW, at day 8, kg−3.6 [−9.1 to −1.7]−0.2 [−1.2 to + 2.5]<.001***
Child-Pugh-Turcotte class, B/C10/65/90.272
MELD score13 [8–22]16 [8–29]0.164
MELDNa score17 [8–30]21 [12–32]0.129
MAP, mmHg81 [65–104]82 [76–106]0.533
Baseline diuretics
 Furosemide, mg/day22.5 [0–60]30 [0–160]0.949
 Spironolactone, mg/day50 [25–100]37.5 [0–75]0.443
Pre-treatment biochemical studies
 Total bilirubin, mg/dL1.5 [0.3–12.6]3.5 [1.1–8.3]0.034*
 PT-INR1.20 [0.96–1.75]1.29 [1.03–2.42]0.429
 Serum sodium, mmol/L134.8 [123.1–142.8]133.4 [122.3–40.0]0.692
 Albumin, g/dL2.5 [1.6–3.1]2.4 [1.8–3.9]0.917
 BUN, mg/dL18.3 [5.9–47.1]23.6 [11.9–46.3]0.085
 Serum creatinine, mg/dL1.00 [0.48–2.49]1.00 [0.48–2.13]0.819
 ALT, IU/L19.5 [7–45]41 [11–75]0.004**
 GGTP, IU/L59.5 [14–264]92 [11–359]0.262
 AVP, pg/mL1.35 [0.8–5.1]2.3 [1.2–6.3]0.026*
 Aldosterone, pg/mL113 [18–407]316 [107–1200]0.013*
 Serum osmolality, mOsm/kg. H2O286 [250–290]282 [273–295]0.880
 Urine osmolality, mOsm/kg. H2O448 [272–691]452 [59–838]0.350
Body Compositions; baseline
 BMI, kg/m223.1 [17.6–32.7]23.7 [16.7–27.7]0.574
 Skeletal muscle index, kg/m29.1 [7.4–16.0]9.3 [7.1–11.5]0.603
 TBWBIA-c a, L/m220.2 [18.0–22.5]20.8 [17.9–24.0]0.575
 ECWBIA-c a, L/m28.3 [7.2–9.2]8.3 [6.7–10.1]0.755
 ICWBIA-c a, L/m212.0 [10.5–13.7]12.4 [9.6–14.0]0.418
 ECWBIA/TBWBIA0.40 [0.38–0.43]0.40 [0.37–0.46]0.418
  1. Data are shown as median with the range within brackets, or numbers
  2. Abbreviations: M Male, F Female, HCV Hepatitis virus C, MELD Model for end-stage liver disease, MAP Mean arterial pressure, PT-INR Prothrombin time- international ratio, BUN Blood urea nitrogen, ALT Alanine transaminase, GGTP γ- glutamyl transpeptidase, AVP Arginine vasopressin, BMI Body mass index, TBW Total body water, BIA Bioimpedance analysis, ECW Extracellular water, ICW Intracellular water
  3. *, P < 0.05; **, P < 0.01; ***, P < 0.0001
  4. aTBWBIA-c, ECWBIA-c, ICWBIA-c were normalized by body surface area (m2)