Variables | Responders | Non-responders | P (uni) |
---|---|---|---|
N | 16 (53%) | 14 (47%) | – |
Age, years | 71 [46–87] | 65 [51–80] | 0.227 |
Sex, M/F | 8/8 | 9/5 | 0.484 |
ΔBW, at day 8, kg | −3.6 [−9.1 to −1.7] | −0.2 [−1.2 to + 2.5] | <.001*** |
Child-Pugh-Turcotte class, B/C | 10/6 | 5/9 | 0.272 |
MELD score | 13 [8–22] | 16 [8–29] | 0.164 |
MELDNa score | 17 [8–30] | 21 [12–32] | 0.129 |
MAP, mmHg | 81 [65–104] | 82 [76–106] | 0.533 |
Baseline diuretics | |||
 Furosemide, mg/day | 22.5 [0–60] | 30 [0–160] | 0.949 |
 Spironolactone, mg/day | 50 [25–100] | 37.5 [0–75] | 0.443 |
Pre-treatment biochemical studies | |||
 Total bilirubin, mg/dL | 1.5 [0.3–12.6] | 3.5 [1.1–8.3] | 0.034* |
 PT-INR | 1.20 [0.96–1.75] | 1.29 [1.03–2.42] | 0.429 |
 Serum sodium, mmol/L | 134.8 [123.1–142.8] | 133.4 [122.3–40.0] | 0.692 |
 Albumin, g/dL | 2.5 [1.6–3.1] | 2.4 [1.8–3.9] | 0.917 |
 BUN, mg/dL | 18.3 [5.9–47.1] | 23.6 [11.9–46.3] | 0.085 |
 Serum creatinine, mg/dL | 1.00 [0.48–2.49] | 1.00 [0.48–2.13] | 0.819 |
 ALT, IU/L | 19.5 [7–45] | 41 [11–75] | 0.004** |
 GGTP, IU/L | 59.5 [14–264] | 92 [11–359] | 0.262 |
 AVP, pg/mL | 1.35 [0.8–5.1] | 2.3 [1.2–6.3] | 0.026* |
 Aldosterone, pg/mL | 113 [18–407] | 316 [107–1200] | 0.013* |
 Serum osmolality, mOsm/kg. H2O | 286 [250–290] | 282 [273–295] | 0.880 |
 Urine osmolality, mOsm/kg. H2O | 448 [272–691] | 452 [59–838] | 0.350 |
Body Compositions; baseline | |||
 BMI, kg/m2 | 23.1 [17.6–32.7] | 23.7 [16.7–27.7] | 0.574 |
 Skeletal muscle index, kg/m2 | 9.1 [7.4–16.0] | 9.3 [7.1–11.5] | 0.603 |
 TBWBIA-c a, L/m2 | 20.2 [18.0–22.5] | 20.8 [17.9–24.0] | 0.575 |
 ECWBIA-c a, L/m2 | 8.3 [7.2–9.2] | 8.3 [6.7–10.1] | 0.755 |
 ICWBIA-c a, L/m2 | 12.0 [10.5–13.7] | 12.4 [9.6–14.0] | 0.418 |
 ECWBIA/TBWBIA | 0.40 [0.38–0.43] | 0.40 [0.37–0.46] | 0.418 |