Fig. 5
Serial monitoring of urine osmolality, serum sodium and blood urea nitrogen and the percent of change in both parameters in patients whose intracellular water decreased or increased after add-on tolvaptan. Patients whose bioimpedance-defined intracellular water (ICWBIA) decreased (open circles with lines) or increased (closed circles with dashed lines) after add-on tolvaptan were compared. Urine osmolality (mOsm/kg. H2O; a), serum sodium (mmol/L; b, left) and blood urea nitrogen (BUN, mg/dL; b, right) were monitored as illustrated in Figure S2, at 0, 6, 24, 72, and 168 h. The combined percent changes in both serum sodium (Na) and urea nitrogen (UN) were compared in ICWBIA decreased/increased cases (c, left) and responders/non-responders (c, right). Spearman correlation analyses of the combined percent changes in both serum sodium (Na) and urea nitrogen (UN) and that of ICWBIA and bioimpedance-defined extracellular water (ECWBIA) were shown in d. Medians with interquartile ranges are shown in bars. *, P < 0.05; **, P < 0.01