Fig. 2
Serial monitoring of bioimpedance-defined intracellular water, extracellular water, and the percent of change in both parameters by bioimpedance analysis after add-on tolvaptan at low doses. Bioimpedance-defined intracellular body water standardized by body surface area (BSA) (ICWBIA-c, L/m2, a, extracellular body water standardized by BSA (ECWBIA-c, L/m2, b, and percent of change in both compartments compared to day 0 (panel c) were monitored as illustrated in Figure S2, at 0, 6, 24, 72, and 168 (missing data: 6 for BIA at 168 h) hours after add-on tolvaptan at low doses was administered. Patients with 1.5 kg or more body weight reduction on day eight were defined as responders (open circles for ICWBIA; open squares for ECWBIA; with thin lines), and others as non-responders (closed upward triangles for ICWBIA; closed downward triangles for ECWBIA; with dashed lines). Medians with interquartile ranges are shown in bars. In panel c, P-values compared ICWs with respect to response are shown, whereas P-values referring to ECWBIA, comparisons are shown in brackets. Abbreviations: ICW, intracellular water; ECW, extracellular water; BIA; bioimpedance analysis; BSA, body surface area; NS, not significant. *, P < 0.05; **, P < 0.01; ***, P < 0.0001