Fig. 1

Serial monitoring of body weight, changes in BW, extracellular water to total body water ratio, and serum sodium concentration after add-on tolvaptan at low doses. Body weight (BW, in kilograms, a, changes in body weight (ΔBW, in kilograms, b, the extracellular water/total body water (ECW/TBW) ratio (using the bioimpedance analysis [BIA] method, c, and serum sodium concentration (in mmol/L, d were monitored as illustrated in Figure S2, at 0, 6, 24, 72, and 168 h (missing data: 6 for BIA at 168 h) after add-on tolvaptan at low doses was administered. Patients with 1.5 kg or more body weight reduction (horizontal light gray line in b) on day eight were defined as responders (open circles); all other patients were defined as non-responders (closed triangles). Medians with interquartile ranges are shown in bars. Abbreviations: ECW, extracellular water; TBW, total body water. *, P < 0.05