Table 1 Quality assement of eligible literatures

RCT study

Author

Prospective design

Clear definition of study population

(1)

(2)

(3)

(4)

(5)

Abraldes, et al. 2009 [21]

Yes

Yes

Yes

Stable

Yes

Yes

Yes

Pollo-Flores, et al. 2015 [32]

Yes

Yes

Yes

Stable

Yes

Yes

Yes

Abraldes, et al. 2016 [22]

Yes

Yes

Yes

Stable

Yes

Yes

Yes

Bishnu, et al. 2018 [24]

Yes

Yes

Yes

Stable

Yes

Yes

Yes

Elwan, et al. 2018 [26]

Yes

Yes

Yes

Stable

Yes

Yes

Yes

Domenico, et al

Yes

Yes

Yes

Stable

Yes

Yes

Yes

non-RCT study

Author

Study design

Clear definition of study population

Clear definition of different type of statin

Clear definition of related endpoints

Blindness to a statin or placebo

Representativeness

of the study population

Comparability between case and control groups

Kumar, et al. 2014 [30]

Propensity Score Matching Case-control Study

Yes

Yes

Yes

No

Yes

Yes

Simon, et al. 2015 [34]

Cohort study

Yes

No

Yes

Not given

Yes

Yes

Yang, et al. 2015 [37]

Propensity Score Matching Case-control Study

Yes

No

Yes

No

Yes

Yes

Huang, et al. 2017 [27]

Propensity Score Matching Case-control Study

Yes

No

Yes

No

Yes

Yes

Mohanty, et al. 2016 [31]

Propensity Score Matching Case-control Study

Yes

Yes

Yes

Not given

Yes

Yes

Simon, et al. 2016 [33]

Case-control Study

Yes

Yes

Yes

No

Yes

Yes

Bang, et al. 2017 [23]

Case-control Study

Yes

No

Yes

No

Yes

Yes

Chang, et al. 2017 [25]

Propensity Score Matching Case-control Study

Yes

No

Yes

Not given

Yes

Yes

Kim, et al. 2017 [13]

Nested Case-control Study

Yes

Yes

Yes

No

Yes

Yes

Wong, et al. 2017 [36]

Propensity Score Matching Case-control Study

Yes

Yes

Yes

No

Yes

Yes

Wani, et al. 2017 [35]

Self-control Study (Prospective Cohort)

Yes

Yes

Yes

No

Yes

Yes

Kaplan, et al. 2019 [28]

Propensity Score Matching Case-control Study

Yes

No

Yes

Not given

Yes

Yes