Fig. 1

Fifteen microscopic features that showed significant differences among the three groups. a: Inflammation involved the submucosa and basal plasmacytosis. HE 100×; b: Uneven inflammation. Inflammation on the left was severe and the right was mild. HE 20×; c: Cryptitis (lower left corner) and crypt abscesses (upper right corner). HE 200×; d: Intra-surface epithelium neutrophil and intra-mucosa neutrophil. HE 400×; e: Erosion showing as superficial epithelial damage. HE 100×; f: Pyloric gland metaplasia with pale cytoplasm. HE 200×; g: Aberrant crypt structure: distorted, non-parallel, and irregular. HE 200×; h: Villi changes (shortening, widening, and blunting) and decrease in intra-epithelial mucus. HE 100×; I: Increased goblet cells. HE 200×; J: Lymphangiectasia. HE 400×; k: Thickened muscularis mucosa. HE 200×; l: non-caseating epithelioid granuloma. HE 400×