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Table 6 Association between liver fibrosis status (continuous measure) and a) CD8+ T-cell b) CD4+ T-cell subsets reflecting immunosenesence among art-naïve PLWHA with recent heavy alcohol use

From: Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study

a)CD8+ CD28- CD57+ (as % of CD8+)
Adjusted Mean Difference (95% CI)P-value
Log(FIB-4) ≤ 16.2 (− 0.70, 13.18)0.08
Log(FIB-4) > 1−5.54 (− 13.6, 2.47)0.17
Age/years−0.06 (− 0.58, 0.45)0.80
Female sex−0.83 (−7.68, 6.01)0.81
Log10(HIV-1 RNA)−0.45 (− 3.15, 2.25)0.74
Heavy drinking1.24 (−8.99, 11.47)0.81
Injection drug use3.54 (−3.12, 10.20)0.30
Current smoking−0.55 (−9.53, 8.43)0.90
Years since HIV diagnosis−0.08 (− 0.68, 0.52)0.79
Hepatitis C4.32 (−5.33, 13.97)0.38
Hepatitis B−3.69 (− 10.34, 2.97)0.27
Shingles0.32 (−6.82, 7.46)0.93
Tuberculosis3.11 (−5.82, 12.04)0.49
b)CD4+ CD28- CD57+ (as% of CD4+)
Adjusted Mean Difference (95% CI)P-value
Log(FIB-4)0.99 (0.64, 1.54)0.97
Age/years1.05 (0.99, 1.10)0.09
Female sex0.83 (0.41, 1.71)0.62
Log10(HIV-1 RNA)0.90 (0.68, 1.20)0.48
Heavy drinking1.07 (0.37, 3.14)0.90
Injection drug use1.09 (0.54, 2.19)0.81
Current smoking0.89 (0.35, 2.27)0.80
Years since HIV diagnosis0.99 (0.93, 1.05)0.68
Hepatitis C0.34 (0.13, 0.93)0.04
Hepatitis B0.62 (0.31, 1.24)0.18
Shingles1.34 (0.63, 2.81)0.44
Tuberculosis0.92 (0.36, 2.36)0.87