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Table 5 a) Unadjusted and b) adjusted association between liver fibrosis status and CD4+ T-cell subsets reflecting immunosenesence among art-naïve PLWHA with recent heavy alcohol use

From: Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study

a)CD4+ CD28- CD57+ (as % of CD4+)CD4+ Memory (as % of CD4+)CD4+ Naïve (as % of CD4+)CD4+ Naïve:Memory ratio
Unadjusted Mean Differencea (95% CI)P-valueUnadjusted Mean Difference (95% CI)P-valueUnadjusted Mean Difference (95% CI)P-valueUnadjusted Mean Differencea (95% CI)P-value
No advanced fibrosis/ cirrhosis1 (referent group) 1 (referent group) 1 (referent group) 1 (referent group) 
Advanced fibrosis/ cirrhosis0.81 (0.39, 1.70)0.582.95 (−4.09, 10.0)0.41−3.83 (−9.28, 1.61)0.170.95 (0.63, 1.44)0.81
b)CD4+ CD28- CD57+ (as % of CD4+)CD4+ Memory (as % of CD4+)CD4+ Naïve (as % of CD4+)CD4+ Naïve:Memory ratio/CD4+
Adjusted Mean Differencea (95% CI)P-valueAdjusted Mean Difference
(95% CI)
P-valueAdjusted Mean Difference (95% CI)P-valueAdjusted Mean Differencea (95% CI)P-value
No advanced fibrosis/ cirrhosis1 (referent group) 1 (referent group) 1 (referent group) 1 (referent group) 
Advanced fibrosis/ cirrhosis1.00 (0.48, 2.07)1.002.15 (−4.89, 9.19)0.55−3.38 (−8.67, 1.91)0.211.00 (0.66, 1.52)0.99
Age/years1.05 (1.00, 1.10)0.070.32 (−0.15, 0.79)0.18−0.37 (− 0.79, 0.04)0.080.98 (0.96, 1.01)0.22
Female sex0.89 (0.46, 1.73)0.73−2.42 (−8.86, 4.02)0.462.97 (− 2.62, 8.57)0.301.14 (0.78, 1.67)0.49
Log10(HIV-1 RNA)0.91 (0.70, 1.18)0.490.79 (−1.75, 3.33)0.54−0.59 (− 2.58, 1.41)0.561.00 (0.86, 1.17)0.96
Heavy drinking0.91 (0.34, 2.39)0.84−4.87 (−14.23, 4.50)0.315.36 (−2.71, 13.43)0.191.27 (0.73, 2.21)0.40
Injection drug use1.09 (0.56, 2.11)0.80−3.11 (−9.50, 3.27)0.343.53 (−1.9, 8.96)0.201.16 (0.80, 1.69)0.43
Current smoking0.80 (0.34, 1.91)0.621.75 (−6.65, 10.15)0.68−2.3 (−9.75, 5.16)0.550.92 (0.56, 1.51)0.73
Years since HIV diagnosis0.98 (0.93, 1.04)0.55−0.06 (− 0.63, 0.51)0.830.11 (− 0.38, 0.6)0.661.00 (0.97, 1.04)0.83
Hepatitis C0.37 (0.14, 0.93)0.04−2.57 (−11.59, 6.45)0.583.49 (−4.52, 11.5)0.391.14 (0.67, 1.94)0.63
Hepatitis B0.62 (0.32, 1.19)0.155.69 (−0.62, 12.01)0.08−5.04 (−10.39, 0.3)0.060.74 (0.51, 1.07)0.11
Shingles1.41 (0.70, 2.84)0.346.13 (−0.63, 12.90)0.08−5.51 (−11.32, 0.31)0.060.71 (0.47, 1.05)0.09
Tuberculosis0.93 (0.38, 2.24)0.861.45 (−7.10, 10.01)0.74−3.64 (−10.84, 3.56)0.320.82 (0.50, 1.37)0.46
  1. aRepresents the ratio of means after back transformation from natural log scale