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Table 4 a) Unadjusted and b)adjusted association between liver fibrosis status and CD8+ T-cell subsets reflecting immunosenesence among art-naïve PLWHA with recent heavy alcohol use

From: Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study

a)CD8+ CD28- CD57+ (as % of CD8+)CD8+ Memory (as % of CD8+)CD8+ Naïve (as % of CD8+)CD8+ Naïve:Memory ratio
Unadjusted Mean Difference (95% CI)P-valueUnadjusted Mean Difference (95% CI)P-valueUnadjusted Mean Difference (95% CI)P-valueUnadjusted Ratio of Meansa (95% CI)P-value
No advanced fibrosis/ cirrhosis1 (referent group) 1 (referent group) 1 (referent group) 1 (referent group) 
Advanced fibrosis/ cirrhosis0.67 (−6.15, 7.48)0.85−2.61 (−8.59, 3.36)0.392.48 (−3.78, 8.73)0.441.24 (0.84, 1.90)0.25
b)CD8+ CD28- CD57+ (as %CD8+)CD8+ Memory (as %CD8+)CD8+ Naïve (as%CD8+)CD8+ Naïve:Memory ratio
Adjusted Mean Difference (95% CI)P-valueAdjusted Mean Difference (95% CI)P-valueAdjusted Mean Difference (95% CI)P-valueAdjusted Mean Difference (95% CI)P-value
No advanced fibrosis/ cirrhosis1 (referent group) 1 (referent group) 1 (referent group) 1 (referent group) 
Advanced fibrosis/ cirrhosis (adjusted)−0.36 (−7.35, 6.63)0.92−3.16 (−8.90, 2.57)0.283.07 (−2.97, 9.11)0.321.32 (0.88, 1.97)0.18
Age/years−0.07 (− 0.39, 0.53)0.77− 0.15 (− 0.53, 0.23)0.450.01 (− 0.39, 0.41)0.961.00 (0.97, 1.03)0.96
Female sex−0.53 (−6.93, 5.87)0.87−3.12 (− 8.37, 2.13)0.242.76 (−2.76, 8.29)0.331.23 (0.85, 1.78)0.27
Log10(HIV-1 RNA copies/mL)−0.18 (−2.70, 2.34)0.892.94 (0.87, 5.01)< 0.01−2.38 (−4.55, − 0.20)0.030.91 (0.79, 1.05)0.20
Heavy drinking−0.15 (−9.45, 9.16)0.98−6.68 (−14.32, 0.95)0.098.27 (0.23, 16.30)0.041.47 (0.86, 2.51)0.16
Injection drug use3.26 (−3.08, 9.60)0.31−1.10 (−6.31, 4.10)0.682.95 (−2.53, 8.42)0.291.26 (0.87, 1.81)0.22
Current smoking−0.17 (−8.51, 8.18)0.975.31 (−1.53, 12.16)0.13−5.58 (− 12.79, 1.63)0.130.74 (0.46, 1.20)0.23
Years since HIV diagnosis−0.16 (− 0.72, 0.41)0.59− 0.24 (− 0.70, 0.22)0.310.65 (0.16, 1.14)< 0.011.03 (1.00, 1.07)0.07
Hepatitis C6.67 (−2.29, 15.63)0.141.5 (−5.84, 8.86)0.69−2.93 (−10.7, 4.81)0.460.89 (0.53, 1.48)0.65
Hepatitis B−3.41 (−9.68, 2.86)0.294.72 (−0.42, 9.87)0.07−5.55 (−11.0, − 0.13)0.040.67 (0.47, 0.97)0.03
Shingles1.70 (−5.02, 8.43)0.623.04 (−2.48, 8.55)0.28−1.64 (−7.44, 4.17)0.580.85 (0.58, 1.25)0.41
Tuberculosis2.43 (−6.07, 10.93)0.58−8.60 (−15.57, − 1.62)0.026.07 (− 1.27, 13.41)0.111.46 (0.89, 2.37)0.13
  1. aResult after back transformation from natural log scale