Table 3 Distribution of CD4+ T-cell subsets reflecting immunosenesence by liver fibrosis status among art-naïve PLWHA with recent heavy alcohol use
T-cell subsets as a proportion of CD4+ T-cells | Mean (SD) unless otherwise stated | p-value | ||
|---|---|---|---|---|
Overall | No advanced fibrosis/cirrhosis | Advanced fibrosis/cirrhosis | ||
CD4 + CD28-CD57+ (25th, 75th) | 2.25 (0.40, 6.40) | 2.40 (0.40, 6.10) | 1.40 (0.40, 6.60) | 0.59 |
CD4+ memory | 54.3 (16.3) | 53.7 (15.1) | 56.6 (20.7) | 0.42 |
CD4+ naive | 38.7 (15.0) | 39.3 (14.0) | 36.4 (18.6) | 0.39 |
CD4+ naïve:memory ratiomedian (25th, 75th) | 0.70 (0.48, 1.07) | 0.75 (0.48, 1.13) | 0.59 (0.47, 1.06) | 0.81 |