Overall | No advanced fibrosis/cirrhosis | Advanced fibrosis/cirrhosis | p-value | |
---|---|---|---|---|
N | 130 | 105 | 25 | – |
Mean age (SD)/years | 33.5 (6.0) | 33.6 (6.2) | 33.1 (4.9) | 0.74 |
Female sex | 33 (25%) | 26 (25%) | 7 (28%) | 0.74 |
Heavy drinkinga | 118 (91%) | 95 (90%) | 23 (92%) | 0.81 |
Injected drugs use (past 30 days) | 46 (35%) | 38 (36%) | 8 (32%) | 0.69 |
Current regular smoker | 111 (85%) | 87 (83%) | 24 (96%) | 0.09 |
Self-reported history of hepatitis B | 43 (33%) | 34 (32%) | 9 (36%) | 0.73 |
Self-reported history of herpes zoster | 28 (22%) | 20 (19%) | 8 (32%) | 0.16 |
Self-reported history of tuberculosis | 16 (12%) | 11 (11%) | 5 (20%) | 0.19 |
Hepatitis C antibody positive | 114 (88%) | 89 (85%) | 25 (100%) | 0.04 |
Mean years since first positive HIV test (SD) | 6.8 (5.0) | 6.7 (4.9) | 7.3 (5.4) | 0.54 |
Mean platelet count (SD) | 211 (74) | 226 (65) | 148 (75) | < 0.01 |
Mean ALT (SD)/Units per liter | 52 (74) | 38 (40) | 109 (136) | < 0.01 |
Mean AST (SD)/Units per liter | 65 (65) | 45 (22) | 148 (107) | < 0.01 |
Median FIB-4 (25th, 75th) | 1.3 [0.9, 2.1] | 1.1 [0.9, 1.5] | 3.4 [2.3, 6.6] | < 0.01 |
Median APRI (25th, 75th) | 0.6 [0.4, 1.0] | 0.5 [0.3, 0.8] | 2.4 [1.5, 4.2] | < 0.01 |
Median Fibroscan (25th, 75th); N = 33 (9 determined to have advanced fibrosis/cirrhosis) | 6.4 [5.3, 8.4] | 6.2 [5.0, 7.2] | 8.0 [7.6, 13.6] | < 0.01 |
Mean Log10 HVL (SD) /copies/mL | 4.5 (1.1) | 4.5 (1.0) | 4.6 (1.3) | 0.85 |