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Table 1 Baseline characteristics of study population by liver fibrosis status among ART-naïve people living with HIV/AIDS (PLWHA) with recent heavy alcohol use

From: Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study

 

Overall

No advanced fibrosis/cirrhosis

Advanced fibrosis/cirrhosis

p-value

N

130

105

25

Mean age (SD)/years

33.5 (6.0)

33.6 (6.2)

33.1 (4.9)

0.74

Female sex

33 (25%)

26 (25%)

7 (28%)

0.74

Heavy drinkinga

118 (91%)

95 (90%)

23 (92%)

0.81

Injected drugs use (past 30 days)

46 (35%)

38 (36%)

8 (32%)

0.69

Current regular smoker

111 (85%)

87 (83%)

24 (96%)

0.09

Self-reported history of hepatitis B

43 (33%)

34 (32%)

9 (36%)

0.73

Self-reported history of herpes zoster

28 (22%)

20 (19%)

8 (32%)

0.16

Self-reported history of tuberculosis

16 (12%)

11 (11%)

5 (20%)

0.19

Hepatitis C antibody positive

114 (88%)

89 (85%)

25 (100%)

0.04

Mean years since first positive HIV test (SD)

6.8 (5.0)

6.7 (4.9)

7.3 (5.4)

0.54

Mean platelet count (SD)

211 (74)

226 (65)

148 (75)

< 0.01

Mean ALT (SD)/Units per liter

52 (74)

38 (40)

109 (136)

< 0.01

Mean AST (SD)/Units per liter

65 (65)

45 (22)

148 (107)

< 0.01

Median FIB-4 (25th, 75th)

1.3 [0.9, 2.1]

1.1 [0.9, 1.5]

3.4 [2.3, 6.6]

< 0.01

Median APRI (25th, 75th)

0.6 [0.4, 1.0]

0.5 [0.3, 0.8]

2.4 [1.5, 4.2]

< 0.01

Median Fibroscan (25th, 75th); N = 33 (9 determined to have advanced fibrosis/cirrhosis)

6.4 [5.3, 8.4]

6.2 [5.0, 7.2]

8.0 [7.6, 13.6]

< 0.01

Mean Log10 HVL (SD) /copies/mL

4.5 (1.1)

4.5 (1.0)

4.6 (1.3)

0.85

  1. a heavy drinking (> 4 standard drinks in a day (or > 14 standard drinks/week) for men and > 3/ day (or > 7/week) for women)
  2. Data are N(%) unless otherwise specified.