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Table 1 Baseline characteristics of study population by liver fibrosis status among ART-naïve people living with HIV/AIDS (PLWHA) with recent heavy alcohol use

From: Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study

 OverallNo advanced fibrosis/cirrhosisAdvanced fibrosis/cirrhosisp-value
N13010525
Mean age (SD)/years33.5 (6.0)33.6 (6.2)33.1 (4.9)0.74
Female sex33 (25%)26 (25%)7 (28%)0.74
Heavy drinkinga118 (91%)95 (90%)23 (92%)0.81
Injected drugs use (past 30 days)46 (35%)38 (36%)8 (32%)0.69
Current regular smoker111 (85%)87 (83%)24 (96%)0.09
Self-reported history of hepatitis B43 (33%)34 (32%)9 (36%)0.73
Self-reported history of herpes zoster28 (22%)20 (19%)8 (32%)0.16
Self-reported history of tuberculosis16 (12%)11 (11%)5 (20%)0.19
Hepatitis C antibody positive114 (88%)89 (85%)25 (100%)0.04
Mean years since first positive HIV test (SD)6.8 (5.0)6.7 (4.9)7.3 (5.4)0.54
Mean platelet count (SD)211 (74)226 (65)148 (75)< 0.01
Mean ALT (SD)/Units per liter52 (74)38 (40)109 (136)< 0.01
Mean AST (SD)/Units per liter65 (65)45 (22)148 (107)< 0.01
Median FIB-4 (25th, 75th)1.3 [0.9, 2.1]1.1 [0.9, 1.5]3.4 [2.3, 6.6]< 0.01
Median APRI (25th, 75th)0.6 [0.4, 1.0]0.5 [0.3, 0.8]2.4 [1.5, 4.2]< 0.01
Median Fibroscan (25th, 75th); N = 33 (9 determined to have advanced fibrosis/cirrhosis)6.4 [5.3, 8.4]6.2 [5.0, 7.2]8.0 [7.6, 13.6]< 0.01
Mean Log10 HVL (SD) /copies/mL4.5 (1.1)4.5 (1.0)4.6 (1.3)0.85
  1. a heavy drinking (> 4 standard drinks in a day (or > 14 standard drinks/week) for men and > 3/ day (or > 7/week) for women)
  2. Data are N(%) unless otherwise specified.