Table 2 Factors associated with severe pruritus (≥5 points of NRS) in PBC patients
|  | NRS < 5 (n = 94) | NRS ≥5 (n = 25) | Univariate analysis |
|---|---|---|---|
P value | |||
Sex (male/female) | 14/80 | 4/21 | 0.891 |
Age (< 65/≥65) | 49/45 | 10/15 | 0.281 |
Leukocyte count (/mm3) | 5375 (2320–13,570) | 5510 (3180–19,720) | 0.606 |
Hemoglobin (g/dL) | 12.9 (8.6–16.9) | 12.1 (7.3–15.0) | 0.086 |
Platelet count (×104/μL) | 20.75 (5.2–48.6) | 20.9 (6.4–51.1) | 0.982 |
Eosinophil count (/mm3) | 130 (0–630) | 110 (10–880) | 0.787 |
Total bilirubin (mg/dL) | 0.7 (0.3–6.8) | 0.7 (0.3–1.6) | 0.606 |
Aspartate aminotransferase (IU/L) | 24.5 (14–164) | 28 (17–73) | 0.055 |
Alanine aminotransferase (IU/L) | 18.5 (10–122) | 23.0 (7–107) | 0.249 |
Alkaline phosphatase (U/L) | 284 (118–2460) | 276 (153–833) | 0.726 |
γ-glutamyl transpeptidase (IU/L) | 35.5 (10–738) | 38.0 (12–505) | 0.405 |
Leucine aminopeptidase (U/L) | 60.5 (30–252) | 62 (36–254) | 0.285 |
Albumin (g/dL) | 4.1 (1.9–5.0) | 4.1 (2.4–4.7) | 0.387 |
Autotaxin (mg/L) | 1.075 (0.577–3.117) | 1.253 (0.719–4.307) | 0.309 |
Estimated glomerular filtration rate (mL/min/1.73 m2) | 104.6 (22.1–177.5) | 70.0 (32.2–164.9) | 0.462 |
HbA1c (%) | 5.7 (3.5–7.0) | 5.8 (4.9–7.1) | 0.765 |
FIB4 index | 1.67 (0.35–10.82) | 1.80 (0.52–8.68) | 0.769 |
History of hepatocellular carcinoma (with/without) | 4/90 | 0/25 | 0.294 |
History of hepatic encephalopathy or varices (with/without) | 0/94 | 0/25 | Â |