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Table 2 Factors associated with severe pruritus (≥5 points of NRS) in PBC patients

From: Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis

  NRS < 5 (n = 94) NRS ≥5 (n = 25) Univariate analysis
P value
Sex (male/female) 14/80 4/21 0.891
Age (< 65/≥65) 49/45 10/15 0.281
Leukocyte count (/mm3) 5375 (2320–13,570) 5510 (3180–19,720) 0.606
Hemoglobin (g/dL) 12.9 (8.6–16.9) 12.1 (7.3–15.0) 0.086
Platelet count (×104/μL) 20.75 (5.2–48.6) 20.9 (6.4–51.1) 0.982
Eosinophil count (/mm3) 130 (0–630) 110 (10–880) 0.787
Total bilirubin (mg/dL) 0.7 (0.3–6.8) 0.7 (0.3–1.6) 0.606
Aspartate aminotransferase (IU/L) 24.5 (14–164) 28 (17–73) 0.055
Alanine aminotransferase (IU/L) 18.5 (10–122) 23.0 (7–107) 0.249
Alkaline phosphatase (U/L) 284 (118–2460) 276 (153–833) 0.726
γ-glutamyl transpeptidase (IU/L) 35.5 (10–738) 38.0 (12–505) 0.405
Leucine aminopeptidase (U/L) 60.5 (30–252) 62 (36–254) 0.285
Albumin (g/dL) 4.1 (1.9–5.0) 4.1 (2.4–4.7) 0.387
Autotaxin (mg/L) 1.075 (0.577–3.117) 1.253 (0.719–4.307) 0.309
Estimated glomerular filtration rate (mL/min/1.73 m2) 104.6 (22.1–177.5) 70.0 (32.2–164.9) 0.462
HbA1c (%) 5.7 (3.5–7.0) 5.8 (4.9–7.1) 0.765
FIB4 index 1.67 (0.35–10.82) 1.80 (0.52–8.68) 0.769
History of hepatocellular carcinoma (with/without) 4/90 0/25 0.294
History of hepatic encephalopathy or varices (with/without) 0/94 0/25  
  1. Categorical data are represented as numbers of patients, and continuous data are represented as the median and range