Table 1 Factors associated with severe pruritus (NRS ≥5 points)
|  | NRS < 5 (n = 2160) | NRS ≥5 (n = 317) | Univariate analysis | Multivariate analysis | |
|---|---|---|---|---|---|
P value | OR (95% CI) | P value | |||
Sex (male/female) | 1074/1086 | 165/152 | 0.439 | Â | Â |
Age (<65/> 65) | 911/1249 | 141/176 | 0.438 |  |  |
Leukocyte count (/mm3) | 5320 (1600–22,510) | 5250 (1900–19,720) | 0.857 |  |  |
Hemoglobin (g/dL) | 13.5 (6.5–17.9) | 13.3 (5.3–17.5) | 0.003 |  |  |
Platelet count (× 104/μL) | 17.8 (2.4–59.5) | 17.7 (2.8–51.1) | 0.576 |  |  |
Eosinophil count (/mm3) | 120 (0–2210) | 140 (0–1260) | 0.003 | 1.001 (1.000–1.002) | 0.002 |
Total bilirubin (mg/dL) | 0.8 (0.2–16.4) | 0.7 (0.2–7.4) | 0.256 |  |  |
Aspartate aminotransferase (IU/L) | 24 (7–1162) | 25 (5–171) | 0.055 |  |  |
Alanine aminotransferase (IU/L) | 19 (1–324) | 20 (3–303) | 0.387 |  |  |
γ-glutamyl transpeptidase (IU/L) | 23 (7–1362) | 27.5 (8–505) | 0.003 |  |  |
Albumin (g/dL) | 4.3 (1.2–5.1) | 4.2 (2.0–5.1) | < 0.001 | 0.637 (0.516–0.787) | <0.001 |
Estimated glomerular filtration rate (mL/min/1.73 m2) | 71.5 (3.9–192) | 70.0 (3.6–181) | 0.022 |  |  |
HbA1c (%) | 5.9 (3.5–12.7) | 5.8 (3.9–8.7) | 0.063 |  |  |
FIB4 index | 2.02 (0.14–51.16) | 2.01 (0.34–331.61) | 0.431 |  |  |
Etiology of liver disease | Â | Â | Â | Â | Â |
 HBV/others | 636/1524 | 82/235 | 0.190 |  |  |
 HCV/others | 979/1181 | 135/182 | 0.360 |  |  |
 AIH/others | 91/2069 | 11/306 | 0.534 |  |  |
 PBC/others | 94/2066 | 25/292 | 0.006 | 2.065 (1.255–3.395) | 0.004 |
 NAFLD/others | 245/1915 | 44/273 | 0.189 |  |  |
 Alcohol/others | 115/2045 | 20/297 | 0.471 |  |  |
History of hepatocellular carcinoma (with/without) | 499/1661 | 73/244 | 0.977 | Â | Â |
History of hepatic encephalopathy or varices (with/without) | 29/2131 | 12/305 | 0.002 | Â | Â |