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Table 1 Factors associated with severe pruritus (NRS ≥5 points)

From: Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis

  NRS < 5 (n = 2160) NRS ≥5 (n = 317) Univariate analysis Multivariate analysis
P value OR (95% CI) P value
Sex (male/female) 1074/1086 165/152 0.439   
Age (<65/> 65) 911/1249 141/176 0.438   
Leukocyte count (/mm3) 5320 (1600–22,510) 5250 (1900–19,720) 0.857   
Hemoglobin (g/dL) 13.5 (6.5–17.9) 13.3 (5.3–17.5) 0.003   
Platelet count (× 104/μL) 17.8 (2.4–59.5) 17.7 (2.8–51.1) 0.576   
Eosinophil count (/mm3) 120 (0–2210) 140 (0–1260) 0.003 1.001 (1.000–1.002) 0.002
Total bilirubin (mg/dL) 0.8 (0.2–16.4) 0.7 (0.2–7.4) 0.256   
Aspartate aminotransferase (IU/L) 24 (7–1162) 25 (5–171) 0.055   
Alanine aminotransferase (IU/L) 19 (1–324) 20 (3–303) 0.387   
γ-glutamyl transpeptidase (IU/L) 23 (7–1362) 27.5 (8–505) 0.003   
Albumin (g/dL) 4.3 (1.2–5.1) 4.2 (2.0–5.1) < 0.001 0.637 (0.516–0.787) <0.001
Estimated glomerular filtration rate (mL/min/1.73 m2) 71.5 (3.9–192) 70.0 (3.6–181) 0.022   
HbA1c (%) 5.9 (3.5–12.7) 5.8 (3.9–8.7) 0.063   
FIB4 index 2.02 (0.14–51.16) 2.01 (0.34–331.61) 0.431   
Etiology of liver disease      
 HBV/others 636/1524 82/235 0.190   
 HCV/others 979/1181 135/182 0.360   
 AIH/others 91/2069 11/306 0.534   
 PBC/others 94/2066 25/292 0.006 2.065 (1.255–3.395) 0.004
 NAFLD/others 245/1915 44/273 0.189   
 Alcohol/others 115/2045 20/297 0.471   
History of hepatocellular carcinoma (with/without) 499/1661 73/244 0.977   
History of hepatic encephalopathy or varices (with/without) 29/2131 12/305 0.002   
  1. Categorical data are represented as numbers of patients, and continuous data are represented as the median and range
  2. HBV hepatitis B virus, HCV hepatitis C virus, AIH autoimmune hepatitis, PBC primary biliary cholangitis, NAFLD non-alcoholic fatty liver disease