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Table 2 Clinicopathologic and molecular characteristics of CRCs

From: Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer

Demographics CIMP-1 (≥4/5) CIMP-2 (≥3/5) CIMP-3 (≥5/8)
Positive (8.5%) Negative P Positive (12%) Negative P High (10.2%) Low (77.3%) Negative (12.5%) P
Age    0.1871    0.1108     0.0296
≤49 15 (3.7%) 108 (26.9%)   22 (5.5%) 101 (25.2%)   20 (5%) 86 (21.4%) 17 (4.2%)  
50–59 11 (2.7%) 135 (33.7%)   14 (3.5%) 132 (32.9%)   11 (2.7%) 120 (29.9%) 15 (3.7%)  
≥60 8 (2%) 124 (30.9%)   12 (3%) 120 (29.9%)   10 (2.5%) 104 (25.9%) 18 (4.5%)  
Gender    0.0046    0.0063     0.0011
Men 11 (2.7%) 217 (54.1%)   18 (4.5%) 210 (52.4%)   13 (3.2%) 186 (46.4%) 29 (7.2%)  
Women 23 (5.7%) 150 (37.4%)   30 (7.5%) 143 (35.7%)   28 (7%) 124 (30.9%) 21 (5.2%)  
Tumor location    0.0142    0.0552     0.0065
Distal 19 (4.7%) 281 (70.1%)   30 (7.5%) 270 (67.3%)   23 (5.7%) 244 (60.8%) 33 (8.2%)  
Proximal 15 (3.7%) 86 (21.4%)   18 (4.5%) 83 (20.7%)   18 (4.5%) 66 (16.5%) 17 (4.2%)  
Stage    0.1697    0.5059     0.5459
I 5 (1.2%) 72 (18.0%)   9 (2.2%) 68 (17%)   6 (1.5%) 61 (15.2%) 10 (2.5%)  
II 17 (4.2%) 144 (35.9%)   24 (6%) 137 (34.2%)   21 (5.2%) 119 (29.7%) 21 (5.2%)  
III 9 (2.2%) 139 (34.7%)   14 (3.5%) 134 (33.4%)   13 (3.2%) 120 (29.9%) 15 (3.7%)  
IV 3 (0.7%) 12 (3.0%)   1 (0.2%) 14 (3.5%)   1 (0.2%) 10 (2.5%) 4 (1%)  
BRAF status    0.2339    0.039     0.2771
Wild type 33 (8.2%) 365 (91.0%)   46 (11.5%) 352 (87.8%)   40 (10%) 308 (76.8%) 50 (12.5%)
Mutation 1 (0.2%) 2 (0.5%)   2 (0.5%) 1 (0.2%)   1 (0.2%) 2 (0.5%) 0 (0)  
KRAS status    0.0957    0.1072     0.1033
Wild type 21 (5.2%) 280 (69.8%)   31 (7.7%) 270 (67.3%)   26 (6.5%) 234 (58.4%) 41 (10.2%)
Mutation 13 (3.2%) 87 (21.7%)   17 (4.2%) 83 (20.7%)   15 (3.7%) 76 (19%) 9 (2.2%)  
MSI status    1    0.287     0.7373
MSS 5 (6.1%) 53 (64.6%)   10 (12.2%) 48 (58.5%)   8 (9.8%) 44 (53.7%) 6 (7.3%)  
MSI-low 1 (1.2%) 18 (22.0%)   2 (2.4%) 17 (20.7%)   2 (2.4%) 15 (18.3%) 2 (2.4%)  
MSI-high 0 (0) 5 (6.1%)   2 (2.4%) 3 (3.7%)   1 (1.2%) 4 (4.9%) 0 (0)  
  1. Bold P value indicates P ≤ 0.05