|
Demographics
|
CIMP-1 (≥4/5)
|
CIMP-2 (≥3/5)
|
CIMP-3 (≥5/8)
|
|---|
|
Positive (8.5%)
|
Negative
|
P
|
Positive (12%)
|
Negative
|
P
|
High (10.2%)
|
Low (77.3%)
|
Negative (12.5%)
|
P
|
|---|
|
Age
| | |
0.1871
| | |
0.1108
| | | |
0.0296
|
|
≤49
|
15 (3.7%)
|
108 (26.9%)
| |
22 (5.5%)
|
101 (25.2%)
| |
20 (5%)
|
86 (21.4%)
|
17 (4.2%)
| |
|
50–59
|
11 (2.7%)
|
135 (33.7%)
| |
14 (3.5%)
|
132 (32.9%)
| |
11 (2.7%)
|
120 (29.9%)
|
15 (3.7%)
| |
|
≥60
|
8 (2%)
|
124 (30.9%)
| |
12 (3%)
|
120 (29.9%)
| |
10 (2.5%)
|
104 (25.9%)
|
18 (4.5%)
| |
|
Gender
| | |
0.0046
| | |
0.0063
| | | |
0.0011
|
|
Men
|
11 (2.7%)
|
217 (54.1%)
| |
18 (4.5%)
|
210 (52.4%)
| |
13 (3.2%)
|
186 (46.4%)
|
29 (7.2%)
| |
|
Women
|
23 (5.7%)
|
150 (37.4%)
| |
30 (7.5%)
|
143 (35.7%)
| |
28 (7%)
|
124 (30.9%)
|
21 (5.2%)
| |
|
Tumor location
| | |
0.0142
| | |
0.0552
| | | |
0.0065
|
|
Distal
|
19 (4.7%)
|
281 (70.1%)
| |
30 (7.5%)
|
270 (67.3%)
| |
23 (5.7%)
|
244 (60.8%)
|
33 (8.2%)
| |
|
Proximal
|
15 (3.7%)
|
86 (21.4%)
| |
18 (4.5%)
|
83 (20.7%)
| |
18 (4.5%)
|
66 (16.5%)
|
17 (4.2%)
| |
|
Stage
| | |
0.1697
| | |
0.5059
| | | |
0.5459
|
|
I
|
5 (1.2%)
|
72 (18.0%)
| |
9 (2.2%)
|
68 (17%)
| |
6 (1.5%)
|
61 (15.2%)
|
10 (2.5%)
| |
|
II
|
17 (4.2%)
|
144 (35.9%)
| |
24 (6%)
|
137 (34.2%)
| |
21 (5.2%)
|
119 (29.7%)
|
21 (5.2%)
| |
|
III
|
9 (2.2%)
|
139 (34.7%)
| |
14 (3.5%)
|
134 (33.4%)
| |
13 (3.2%)
|
120 (29.9%)
|
15 (3.7%)
| |
|
IV
|
3 (0.7%)
|
12 (3.0%)
| |
1 (0.2%)
|
14 (3.5%)
| |
1 (0.2%)
|
10 (2.5%)
|
4 (1%)
| |
|
BRAF status
| | |
0.2339
| | |
0.039
| | | |
0.2771
|
|
Wild type
|
33 (8.2%)
|
365 (91.0%)
| |
46 (11.5%)
|
352 (87.8%)
| |
40 (10%)
|
308 (76.8%)
|
50 (12.5%)
|
|
Mutation
|
1 (0.2%)
|
2 (0.5%)
| |
2 (0.5%)
|
1 (0.2%)
| |
1 (0.2%)
|
2 (0.5%)
|
0 (0)
| |
|
KRAS status
| | |
0.0957
| | |
0.1072
| | | |
0.1033
|
|
Wild type
|
21 (5.2%)
|
280 (69.8%)
| |
31 (7.7%)
|
270 (67.3%)
| |
26 (6.5%)
|
234 (58.4%)
|
41 (10.2%)
|
|
Mutation
|
13 (3.2%)
|
87 (21.7%)
| |
17 (4.2%)
|
83 (20.7%)
| |
15 (3.7%)
|
76 (19%)
|
9 (2.2%)
| |
|
MSI status
| | |
1
| | |
0.287
| | | |
0.7373
|
|
MSS
|
5 (6.1%)
|
53 (64.6%)
| |
10 (12.2%)
|
48 (58.5%)
| |
8 (9.8%)
|
44 (53.7%)
|
6 (7.3%)
| |
|
MSI-low
|
1 (1.2%)
|
18 (22.0%)
| |
2 (2.4%)
|
17 (20.7%)
| |
2 (2.4%)
|
15 (18.3%)
|
2 (2.4%)
| |
|
MSI-high
|
0 (0)
|
5 (6.1%)
| |
2 (2.4%)
|
3 (3.7%)
| |
1 (1.2%)
|
4 (4.9%)
|
0 (0)
| |
- Bold P value indicates P ≤ 0.05
